摘要
目的了解医院5年常见病原菌分布及耐药性,为控制医院感染提供依据。方法对医院2007年1月-2011年12月培养分离出的29 594株病原菌分布和耐药性进行统计与分析。结果 29 594株感染病原菌中,革兰阳性球菌3722株占12.6%;革兰阴性杆菌9436株占31.9%;真菌5562株占18.8%;各感染菌株数均逐年增多,革兰阴性杆菌构成比呈逐年上升趋势,革兰阳性球菌和真菌呈逐年下降趋势;革兰阳性球菌以凝固酶阴性葡萄球菌为主,革兰阴性杆菌以铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌为主;MRSA检出率有下降趋势,MRC-NS呈明显上升趋势;金黄色葡萄球菌和凝固酶阴性葡萄球菌耐药率在2011年有所下降,肠球菌属的耐药率一直居高不下,铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌的耐药率在2010年有下降趋势。结论对细菌耐药性进行定期监测有助于了解细菌耐药性的变迁,为临床合理用药提供理论依据。
OBJECTIVE To investigate the distribution and drug resistance of common pathogenic bacteria in the hospital during the past five years. METHODS The distribution and drug resistance of 29 594 strains of pathogenic bacteria isolated from Jan 2007 to Dec 2011 were statistically analyzed. RESULTS Of totally 29 594 strains of pathogens causing infections, there were 3722 （12.6%） strains of gram-positive cocci, 9436 （31.9%） strains of gram-negative bacilli,and 5562 （18.8 %） strains of gungi. The strains increased year by year, the constituent ratio of the gram-negative bacilli kept an upward tendency, while the gram-positive cocci and the fungi decreased. The coagulase-negative Staphylococcus was dominant in the gram-positive cocci, and the Pseudornonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae were the predominant species of gram-negative bacilli. The detection rate of MRSA was decreased, while MRCNS increasing obviously. The drug resistance rates of both Staphyloccocus aureus and coagulase-negative Staphylococcus were decreased in 2011, the drug resistance rate of the Enterococci remained high,and the drug resistanee rates of the P. aeruginosa, E. coli, and K. pneumoniae kept a downward tendeney in 2010. CONCLUSION Regular surveillance of antimicrobial resistanee of the clinical isolates can contribute to the understanding of the trend of antimicrobial resistance and provide theoretical basis for rational antimicrobial therapy.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2489-2491,共3页
Chinese Journal of Nosocomiology
基金
安徽省自然基金(09020103002)
关键词
医院感染
病原菌
分布
耐药性
Nosocomial infection
Pathogen
Distribution
Drug resistance
