摘要
目的探讨血液病患者反复血小板输注的治疗效果与人类组织相容性抗原（ＨＬＡ）之间的相关性。方法采用微量淋巴细胞毒试验（ＬＣＴ）和免疫磁珠ＨＬＡⅠ类分型，观察了１２６例反复接受血小板输注的住院患者，血小板增加修正值（ＣＣＩ）与ＬＣＴ的关系。结果血小板输注有效４８例，ＬＣＴ阳性率４％，无效７８例ＬＣＴ阳性率５０％。血小板输注无效与ＬＣＴ阳性率、ＬＣＴ强度之间相关联（Ｐ＜００１）。患者ＨＬＡＡ２基因频率为０９１，与健康人群０５４相比显著增高。结论ＬＣＴ阳性是造成患者血小板输注无效的主要免疫因素。应将ＣＣＩ和ＬＣＴ测算列入反复输注血小板治疗患者的常规检测项目。
Objective To explore the relationship between the effects of platelet transfusion and histocompatibility antigen (HLA). Methods The relationship between the corrected count increment (CCI) of platelet with lymphocytotoxicity test (LCT) and human histocompatibity antigen system Ⅰ subtype (HLA Ⅰ) in 126 hospitalized patients who accepted platelet transfusion. Results Ineffective platelet transfusion was strongly related to LCT positive and LCT intensity ( P <0.01). The HLA A 2 gene frequency was 0.91 The frequency was much higher than that of health human being (0.54). Conclusion Positive LCT was mainly immune factor for ineffective platelet transfusion. CCI and LCT should be the routine test for platelet patients. It may improve the effects of platelet transfusion.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1998年第11期824-826,共3页
National Medical Journal of China
基金
广东省科委重点攻关项目
关键词
血液病
组织相容性抗原
血小板输注
Platelet transfusion Antilymphocyte serum HLA antigen
