摘要
应用标准的微量淋巴细胞毒试验,对反复输血的患者进行了血清中 HLA 抗体筛选及特异性鉴定。同时检测了血小板相关抗体。结果 HLA 抗体的检出率为39.14%(119/304例),其中24.37%(29/119例)的抗体具有特异性,血小板相关抗体阳性率为39.83%(47/118例)。HLA 抗体的阳性频率随输血次数及供血者人数的增加而增高,差异显著。非溶血性输血反应与 HLA 抗体相关。输注浓缩粒细胞后 HLA 抗体的阳性频率最高。本文提出了一些预防及减少输血反应的措施。
A standard microlymphocytotoxicity assay was used to test the sera for HLAantibodies in the patients receiving multitransfusions and to identify their speci-ficity,and at the same time the platelet-associated antibodies were detected.As a result,the dectable rate of HLA antibodies was 39.14% (119/304),of which24.37% (29/119) had specificity;the positive rat platelet-associated antibodieswas 39.83% (47/118).The frequency of positive incidence of HLA antibodiesincreased with the number of transfusions and donors,having a significant differ-ence.The nonhemolytic reaction to transfusion was associated with HLA antibodi-es.The frequency of positive incidence of HLA antibodies was the highest whenthe patients were transfused with concentrated granulocytes.There were takensome measures to prevent and reduce the transfusion reaction.
出处
《中国输血杂志》
CAS
CSCD
1993年第2期65-67,共3页
Chinese Journal of Blood Transfusion
关键词
输血
人白细胞抗原
输血反应
Blood transfusion
HLA antibody
Platelet-associated antibody
Nonhemolytic reaction to transfusion
