摘要
目的:探讨多种眼表因素异常在糖尿病患者干眼症发病中的作用。方法:50例2型糖尿病患者存在的干眼症状及有关的眼表因素(角膜上皮完整性、泪液基础分泌、泪膜稳定性、结膜上皮鳞状化生程度、杯状细胞密度)检查结果量化后进行单因素及多因素的非条件Logistic回归分析。结果:泪液基础分泌量减少(P=0.012,OR=6.792),泪膜稳定性下降(P=0.043,OR=4.713),结膜杯状细胞密度下降(P=0.024,OR=0.400)与糖尿病患者干眼症发生呈显著正相关,差异有统计学意义。结论:泪膜稳定性下降、泪液基础分泌量减少及杯状细胞密度下降在2型糖尿病患者干眼症的发病中起一定作用。
AIM：To explore the relationship between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus. METHODS： Fifty cases with type 2 diabetes mellitus were selected and evaluated with the staining with fluorescein sodium on cornea and the tears ferning , a series of ocular testing of the Schirmer I, the tears film stability, the grade of squamous metaplasia, the goblet cell density. A questionnaire about dry eye was surveyed One-way and multivariate non-conditional logistic regression analysis were used to analyze the relation between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus. RESULTS： The decrease of basal tears secretion （ P = 0. 012,OR =6.792）, the unstable tears flilm （P=0.043 ,OR = 4. 713） and lower goblet cell density （ P = 0. 024, OR = 0.400） had positive relationship with the development of dry eye in type 2 diabetes mellitus. CONCLUSION： Our data shows that the unstable tear flilm , the decrease of basal tears secretion and lower goblet cell density might play a role in the development of dry eye in type 2 diabetes mellitus.
出处
《国际眼科杂志》
CAS
2009年第10期1916-1918,共3页
International Eye Science
