摘要
本研究通过对脑梗塞核心家系的分析,探讨了遗传因素在核心家系成员中所起作用的程度,结果表明:病例核心家系脑梗塞家族史的比例显著高于对照,X^2=18.41,P<0.001,不同血缘亲属均有不同程度的脑梗塞患病率,从0.93%到12.84%,病例组各亲属中,不论男女和年龄,SMR 均明显高于正常人群的100,经统计学 Z 检验有极显著意义,病例核心家系的 RR、AR和调整率也明显较高,进一步说明血缘关系与脑梗塞之间有较强的联系,RR 高达4.34～6.10,而对照组的 SMR、RR、AR 和调整率似与血缘无关。
A genetic epidemiologic case-control study including 214 pedigrees(109 cases and 105 controls)was carried out to estimate the genetic susceptibility in nuclear family members of arteriosclerotic cerebral infarction(ACI)in Yi-Xing city,March 1997.The results showed that the nuclear family members were well comparatively,and the proportion of family history of ACI in cases was significantly higher than that in controls,x^2=18.41,P< 0.001.The prevalence of ACI were from 0.93% to 12.84% in different blood relatives.All SMR of the blood relatives in cases nuclear family were also higher than 100 which was in the general population.RR,AR and ad- justed rate of ACI in cases' nuclear family were also higher.It means that there was a stronger association be- tween blood relatives and ACI,and the RR were 4.34～6.10,but there were no association found among RR, AR,adjusted rate and blood relatives in controls.
出处
《现代预防医学》
CAS
1998年第4期414-416,440,共4页
Modern Preventive Medicine
关键词
脑梗塞
核心家系
遗传易感性
流行病学
Arteriosclerotic cerebral infarction
Nuclear family
Genetic susceptibility
