摘要
研究了氧氟沙星与７，７，８，８－四氰基对二次甲基苯醌（ＴＣＮＱ）的荷移反应，确定了反应的最佳条件。在甲醇－丙酮（３：２）介质中，二者于３０℃水浴中恒温３０ｍｉｎ即可形成１：１络合物。在测定波长 ７４３ ｎｍ处络合物的表观摩尔吸光系数为 ３．５８ ×ｌ０４ Ｌ· ｍｏｌ－１·ｃｍ－１；氧氟沙星浓度在０－ １５ ｍｇ／Ｌ范围内符合比尔定律。方法的相对标准差小于３％。
The charge-transfer(CT) complex formed between ofloxacin as the donor and 7, 7, 8, 8-tetra cyanoquinodimethanethane (TCNQ ) as the acceptor in methanol - acetone medium has been studied by spectro photometric method. Beer's law is obeyed in the range of 0 - 15 mg/L of ofloxacin. The apparent absorptivity of CT complex at 743 nm is 3. 58 × １０４Ｌ·mol-1·cm-1· The composition of CT complex is found to be l: 1 by Bent-French and curved intersection methods. The relative standard deviation is less than 3% (n = 8). The method has been applied to the determination of ofloxacin in tablets with satisfactory results.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1998年第7期840-842,共3页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金资助课题!(293626001)
关键词
荷移反应
分光光度法
TCNQ
测定
氧氟沙星
Charge-transfer reaction, 7, 7, 8, 8 - tetracyanoquinodimethane, spectrophotometry, ofloxacin
