摘要
以马来酸氯本那敏 (商品名扑尔敏 )作为电荷给体 ,7,7,8,8 四氰基对二次甲基苯醌 (TCNQ)作为电子受体 ,研究了它们之间形成电荷转移络合物的最佳条件。结果表明 :在丙酮介质中 ,二者于室温 (2 0℃ )下 30min即可形成 1∶2络合物 ,室温下至少稳定 2h。络合物的最大吸收波长为 84 5nm。表观摩尔吸光系数ε为4 6 3× 10 4L·mol-1·cm-1,在 0～ 6mg/L范围内符合比尔定律。方法的相对标准偏差为 1.2 % (n =10 )。对形成荷移络合物的机理进行了探讨 ;用拟定的方法对片剂样品中马来酸氯本那敏的含量进行了测定 ,结果与药典方法一致 。
A spectrophotometric method for the determination of chlorpheniraminum has been developed based on the charge transfer (CT) reaction. The reaction between chlorpheniraminum and 7,7,8,8-tetracyanoquinodemethane (TCNQ) was completed in acetone medium within 30 min at room temperature. The charge transfer complex is stable at least 2 h. Beer's law is obeyed in the range of 0 similar to 6 mg/L of chlorpheniraminum. The, molar absorptivity of the complex at 845 nm was 4.63 x 10(4) L.mol(-1).cm(-1). The relative standard deviation was 1.2% (n = 10). The composition of the complex was found to be 1:2 by slope ratio and Bent-French methods. The mechanism, of reaction was investigated. The method has been applied to the determination of chlorpheniraminum in tablet with satisfactory results.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2003年第11期1327-1329,共3页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金资助项目 (No .2 93 92 60 1)
