摘要
目的:分析导致急性进展性后循环脑梗死(ACIPPC)病情进展的危险因素及血浆基质金属蛋白酶-9(MMP-9)的预测作用。方法:以ACIPPC患者为研究对象,通过与急性非进展性后循环脑梗死(N-ACIPPC)患者进行单因素对比分析,运用logistic(Forward:Wald法)逐步回归分析筛选脑梗死进展的独立危险因素,并通过直线相关分析与回归分析研究血浆MMP-9对ACIPPC梗死灶弥散加权成像(DWI)体积的预测作用。结果:单因素分析表明,ACIPPC和N-ACIPPC患者在高血压病及糖尿病病史、吞咽功能、病情严重程度、随机血糖及血浆MMP-9水平等方面的差异有统计学意义(P<0.05)。Logistic逐步回归分析显示,病情严重程度、随机血糖及血浆MMP-9水平可作为ACIPPC的独立危险因素。直线相关分析与回归分析表明,血浆MMP-9水平为ACIPPC患者梗死灶DWI体积的预测因素。结论:ACIPPC的发生可能为多种因素共同作用的结果,其病情严重程度、随机血糖及血浆MMP-9水平为ACIPPC的独立危险因素,而血浆MMP-9水平为ACIPPC患者梗死灶DWI体积的最有力预测因素。
Objective：To analyze the risk factors for acute cerebral infarct progression in posterior circulation （ACIPPC）and predicting function of plasma MMP-9. Methods：In this study we focused on ACIPPC and compared factors between ACIPPC and N-ACIPPC by single factor analysis, and sieved the independent risk factors for ACIPPC by logistic （Forward：Wald）analysis and demonstrated the predicting role of plasma MMP-9 to the infarction volume of ACIPPC by linear correlation and regression analysis. Results： Single factor analysis showed that hypertension history, diabetes mellitus history, dysphagia, neurological severity,blood glucose and plasma MMP-9 were significanth different between ACIPPC and N-ACIPPC （ P 〈 0.05 ）. Logistic regression analysis indicated that blood glucose, neurological severity and plasma MMP-9 were independent risk factors for ACIPPC. Linear correlation and regression analysis manifested that plasma MMP-9 was a predicting factor for the DWI volume of ACIPPC patients. Conclusion： ACIPPC results from multi-factors, while blood glucose, neurological severity and plasma MMP-9 are independent risk factors for ACIPPC, and plasma MMP-9 may be a predicting factor for the brain stroke volume of DWI in ACIPPC patients.
出处
《临床误诊误治》
2009年第8期7-9,共3页
Clinical Misdiagnosis & Mistherapy
关键词
脑梗死
危险因素
明胶酶B
相关性
Cerebral Infarction
Risk factor
Gelatinase B
Relevance
