摘要
目的研究血浆基质金属蛋白酶-9（MMP-9）预测缺血性脑卒中出血转化的精确度。方法纳入血浆MMP-9预测急性缺血性脑卒中出血转化的临床研究，对血浆MMP-9预测急性缺血性脑卒中出血转化的临床研究进行检索和评价，提取精确度指标，使用Revman4．2和SPSS11．0进行统计学处理。结果（1）共纳入5个研究，包括497例缺血性脑卒中患者，出血转化者109例（21．9％）。纳入研究的方法学质量较高，但异质性较大（Χ^2=30．27，P〈0．01）。（2）亚组分析结果显示，合并诊断比值比为57．25（95％CI：23．57～139．04），合并特异度达89．9％（95％CI：86．4％～93．5％），合并灵敏度为86．5％（95％CI：77．3％～96．8％）。结论血浆MMP-9水平可能能预测急性缺血性脑卒中出血转化；但病例数较少，还需要研究证实。
Objective To study the accuracy of plasma matrix metalloproteinase-9 （MMP-9） predicting hemorrhagic transformation （HT） in ischemic stroke. Methods The studies on plasma MMP-9 predicting HT in ischemic stroke were included, in which diagnostic criteria, methods, and subjects were clearly described, regardless of language of publication and type of studies. MEDLINE （Apr, 1966 to 2006）, EMBase （Apt, 1966 to 2006）, CNKI （Feb, 1977 to 2006 ）, and wanfangshuju （1989 to 2005 ） were searched and the references lists of eligible studies were manually searched. Two reviewers independently evaluated the quality of studies and extracted data. The data were analyzed using the Revman 4.2 or SPSS 11.0. Results Five trials including 497 patients fulfilled the inclusion criteria, 109 of the 497 patients developed HT. The heterogeneity among studies was great （Χ^2 = 30. 27, P 〈 0.01 ）. By subgroup analysis, the plasma MMP-9 level was an independent predictor for HT. The incorporative diagnostic odds ratio was 57. 25 （95% CI： 23.57-139. 04） , summary specialty 89. 9% （95% CI： 86.4%-93. 5% ）, sensitivity 86. 5% （95% CI： 77. 3%-96. 8% ）. Conclusions The values of plasma MMP-9 may be an independent predictor of hemorrhagic transformation. The number of patients in the included studies is not large enough, and the results need to be confirmed in further studies.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2008年第10期704-707,共4页
Chinese Journal of Neurology
基金
高等学校博士学科点专项科研基金资助项目（20030610085）
关键词
脑血管意外
脑出血
明胶酶B
血栓溶解疗法
Cerebrovascular accident
Cerebral hemorrhage
Gelatinase B
Thrombolytic therapy
