摘要
目的探讨急性脑梗死患者血清基质金属蛋白酶9(MMP-9)和外周血白细胞计数变化规律及灯盏细辛干扰的影响。方法选择急性脑梗死患者80例,随机分为灯盏细辛组和常规组,每组40例,健康体检者40例作为对照组。分别于用药前和用药后5、14天测定血清MMP-9的水平,并进行测定外周血白细胞计数。结果与对照组比较,常规组发病24 h内MMP-9水平和白细胞计数明显升高(P<0.05),发病5天达高峰(P<0.01),发病14天降至正常水平。相关性分析,MMP-9与白细胞呈正相关(r=0.9186,P<0.01);灯盏细辛组治疗后14天,爱丁堡+斯堪的那维亚神经功能缺损评分及Barthel指数较常规组明显下降(P<0.01)。结论脑梗死患者急性期MMP-9及白细胞计数明显增高,灯盏细辛注射液能阻碍介导炎性反应的细胞因子的产生,参与了抗炎过程。
Objective To investigate the changes of serum matrix metallo-proteinase-9 （MMP-9） and peripheral leucocyte count in geriatric patients with acute cerebral infarction（ACI） and the effect of Erigeron breviscapus intervention. Methods Eighty geriatric patients with ACI were divided stochastically into two groups： Erigeron breviscapus group and conventional treatment group, and each group had 40 cases. Forty persons who participated in physical exam served as controls. Before and 5 and 14 days after medication, serum MMP-9 levels were measured and peripheral leucocyte count was determined. Results Compared with the control group,MMP-9 and the leucocyte levels in patients receiving conventional treatment increased obviously （P 〈 0.05）, reached the peak level on day 5 （P〈 0. 01）, and declined to the normal level after 14 days. MMP-9 level and the leucocyte count were positively correlated （r = 0. 9186 ,P 〈 0.01）. In Erigeron breviscapus group, 14 days after medication, SNFD and Barthel index dropped obviously （P 〈 0.01） compared with the conventional treatment group. Conclusion The MMP-9 level and the peripheral leucocyte count increased obviously in patients with ACI. The Erigeron breviscapus injection can hinder the production of cytokines intermediating inflammation response,and partici- pate in the anti-inflammation process.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2009年第8期591-593,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
脑梗塞
明胶酶B
灯盏细辛
白细胞计数
内皮细胞
brain infarction
gelatinase B
ERIGERON BREVISCAPUS
leukocyte count
endothelial cells
