摘要
目的比较替考拉宁和万古霉素治疗下呼吸道感染革兰阳性球菌的疗效和安全性。方法对80例应用国产替考拉宁治疗和72例应用万古霉素治疗下呼吸道感染的革兰阳性球菌患者的疗效、细菌清除率及不良反应进行统计学分析。结果国产替考拉宁和万古霉素治疗下呼吸道感染革兰阳性球菌的疗效均较好,国产替考拉宁的有效率为87.5%,细菌清除率为87.5%;万古霉素的有效率为86.1%,细菌清除率为88.9%;两者的有效率和细菌清除率比较差异无统计学意义(P>0.05);两种药物均有一定的药物不良反应发生,其中万古霉素组略多。结论国产替考拉宁和万古霉素是治疗下呼吸道感染革兰阳性球菌的有效药物,国产替考拉宁较万古霉素药物不良反应更小。
OBJECTIVE To evaluate the efficacy and safety of teicoplanin and vancomycin on the treatment of in lower respiratory tract infection Gram-positive （G^＋ ） cocci. METHODS Eighty lower respiratory tract infection patients with G^＋ cocci were treated with teicoplanin, and seventy-two were treated with vancomycin. The therapeutic effect, clearance rate of pathogens, and side effect were compared. RESULTS The clinic effective rate of teicoplanin was 87.5 %, vancomycin was 86. 1%. Teicoplanin was as effective as vancomycin（P〉 0.05）. The clearance rate of pathogens of teicoplanin was 87. 5% and vancomycin was 88. 9%. There was no significant difference between them. Both drugs had side effects. The side effects of vancomycin was a little more than teicoplanin. CONCLUSIONS Both vancomycin and teicoplanin are effective drugs in the treatment of G^＋ cocci in lower respiratory tract infection. The side effects of teicoplanin are smaller than of vancomycin.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第16期2172-2175,共4页
Chinese Journal of Nosocomiology
关键词
替考拉宁
万古霉素
下呼吸道感染
革兰阳性球菌
Teicoplanin
Vancomycin
Lower respiratory tract infection
Gram-positive cocci
