摘要
目的临床观察国产替考拉宁治疗革兰阳性球菌所致的重症肺炎疗效和不良反应以及细菌清除率。方法对青岛大学医学院附属医院2008年8月-2011年8月被确诊为革兰阳性球菌重症肺炎36例住院患者,应用国产替考拉宁治疗,疗程10～14d,并进行临床疗效、细菌清除率及不良反应的比对分析。结果痰培养共检出耐甲氧西林金黄色葡萄球菌(MRSA)25株,耐甲氧西林表皮葡萄球菌(MRSE)4株,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)3株,血培养MRCNS 1株,深部静脉导管末端培养MRSA 2株,临床总有效率为88.89%,细菌清除率为77.78%;不良反应发生率为8.33%,不良反应发生率低。结论国产替考拉宁治疗革兰阳性球菌肺炎疗效确切、安全性高。
OBJECTIVE To observe the efficacy, adverse reactions, and the bacterial clearance rate of the domestic teicoplanin in the treatment of severe pneumonia caused by the gram-positive cocci. METHODS A total of 36 hospitalized patients with definite severe pneumonia caused by the gram-positive cocci were treated with domestic teicoplanin in the Affiliated Hospital of Medical College of Qingdao University from Aug 2008 to Aug 2011. The duration of the treatment was 10~14 d. The therapeutic effect, bacterial clearance rate, and adverse reactions were compared. RESULTS There were totally 25 strains of methicillin-resistant Staphylococus aureus （MRSA） cultured from the sputum specimens, 4 strains of methicillin-resistan Staphylococcus epiclermidis （MRSE）, and 3 strains of methicillin-resistant coagulase-negatiae Staphylococcus （MRCNS）, and there was I strain of MRCNS cultured from the blood. There were 2 cases with the deep venous catheter tip cultured for MRSA. The total clini- cal effective rate was 88.89%, the bacterial clearance rate was 77.78%, and the incidence of the adverse reactions was 8.33 %, which was low. CONCLUSION Domestic teicoplanin has accurate therapeutic effectiveness and is safe for the treatment of pneumonia caused by the gram-positive cocci.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第12期2977-2979,共3页
Chinese Journal of Nosocomiology
基金
青岛市科技局资助项目(09-2-2-3-msh-5)
关键词
替考拉宁
革兰阳性球菌
重症肺炎
临床疗效
Teicoplanin
Gram-positive cocci
Severe pneumonia
Clinical efficacy
