摘要
使用CNDO／2方法对5'－甲叉－CAMP和CGMP的分子电子结构进行计算，基于得到的电荷分布讨论了两种环核苷酸与蛋白激酶作用的可能机理和碱基在调节两种环核苷酸活性方面的可能作用。还分析了两种环核苷酸中存在的分子内氢键及其对稳定构象的作用。
The electronic structures of the cyclic nucleotides cAMP and cGMP are calculated by means of the CNDO/2 method. On basis of the computed charge distributions in the mentioned nucleotides and protein kinase has been discussed. The essential part in the interaction perhaps is the sugar-cycli phosphate. The possible actions of bases in regulating the activity of the two nucleotides are also discussed. In addition the action of stabilizing conformation by hydrogen bonds in both nucleotids cAMP and cGMP are analyzed.
出处
《食品科学》
EI
CAS
CSCD
北大核心
1998年第8期7-11,共5页
Food Science
关键词
环磷酸腺苷
环磷酸岛苷
环核苷酸
蛋白激酶
香菇
Complect neglect of differential overlap method(CNDO/2) Cyclic adenosine monophosphate (cAMP) Cyclic guanosine monophosphate(cGMP) Cyclic nucleotides Protein kinase
