摘要
目的探索中国人群胃癌和吸烟的关系,并对不同性别和吸烟量进行亚组分析。方法所有数据来自中国期刊网全文数据库、维普数据、万方数据库、Science Direct和Pubmed医学数据库。统一制定文献评价标准,由两位研究者独立检索文献,独立对文献进行质量评价和提取信息。利用软件STATA中的Meta analysis模块进行统计分析。结果共纳入文献51篇(11260例病例)。在合计人群中,吸烟是胃癌发病的危险因素(OR=1.66,95%CI:1.47～1.87)。在男性中,吸烟是胃癌的危险因素(OR=1.93,95%CI:1.35～2.76),但在女性中却并未发现吸烟是胃癌的危险因素(OR=1.05,95%CI:0.67～1.64)。按吸烟量的不同,把吸烟分为轻度吸烟、中度吸烟、重度吸烟,通过Meta回归得到:LnOR=0.404×group-0.361,说明吸烟量每增加一个等级,胃癌的发病率会变为原来的1.5倍。结论吸烟是中国人群胃癌的危险因素之一,但在女性这种关系还需进一步研究。吸烟量不同对胃癌的发病率会产生影响。
Objective To analysis and explore the relationship between smoking and gastric cancer in Chinese population. Methods Five medical databases were searched, including CNKI, VIP Information, WANFANG Data, ScienceDirect OnSite and Medline. Two qualified reviewers searched articles, evaluated their quality and extracted data independently. Data was analyzed by Meta analysis with Stata9.2. Results 51 case-control studies were included totally. In Chinese population, smoking was a risk factor for gastric cancer （OR=1.66, 95%CI：1.47-1.87）, while the total pooling ORs were 1.932 （95%CI： 1.348-2.758） and 1.051 （95%CI： 0.672-1.644） in male and female population respectively. The regression function about the relationship between the amount of smoking and gastric cancer was LnOR =0.404 ×group -0.361. Conclusion Smoking is one of the risk factors of gastric cancer. However in the female population, the statistic significance cannot be found. The result of Meta regression indicates that the incidence of gastric cancer increases along with the amount of smoking.
出处
《中国慢性病预防与控制》
CAS
北大核心
2009年第3期247-251,共5页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
吸烟
胃癌
META分析
Smoking
Gastric Cancer
, Meta-analysis
