摘要
目的探讨胃癌患者的ABO血型分布及临床特点。方法选择400例胃癌患者的住院病历资料,分析其ABO血型;比较前后5年患者的ABO血型分布,分析后5年患者的一般情况、首发症状、病理特点。结果与前5年比较,后5年A型血检出率明显减少(41.5%vs 23.5%,P<0.01),O型血检出率明显增多(27.5%vs 42.5%,P<0.01),B型、AB型血无统计学差异。后5年中,各血型患者的首发症状均以上腹痛、腹胀、纳差、体质量下降为主;B型血低分化腺癌患者明显高于A型血患者(68.1%vs 36.1%,P<0.05),70.7%浸润深度达全层,且66.4%有淋巴结转移;累及周围组织的AB型血患者明显高于B型血患者(61.5%vs 25.5%,P<0.05)。结论前后5年胃癌患者的ABO血型分布发生了变化;提示非遗传因素对胃癌发病的影响逐渐增强,血型可能与肿瘤的生物学行为有关。
Objective To explore the distribution of ABO blood group and the clinical features of the patients with gastric cancer （GC）. Methods Inpatient medical records of four hundred cases of the patients with GC were choosed and put into statistical analysis of ABO blood group ; To compare the distribution of ABO blood group of the patients before and after five years, at the same time analyzing the clinical data of the patients included the generaleonditions, clinical manifes- tation, pathological features, auxiliary examination, staging, treat ment and so on. Results Compared with the prior five years, the detectable rate of A blood group was greatly decreased in the recent five years （41.5% vs 23.5% , P 〈0.01 ）, the detectable rate of 0 blood group was obviously increased in the recent five years （27.5% vs 42.5% , P 〈0.01 ） , the discrepancy of B blood group and AB blood group were not statistically significant. In the recent five years, initial symptoms in each blood type group were mainly upper abdominal pain or distention, anorexia, marasmus ; The rates of poorly differen- tiated adenocarcinoma of B blood group were obvious higher than those of A blood group （68.1% vs 36.1% , P 〈 0.05 ）, the invasive depth of 70.7% eases came up to full-thickness, about 66.4% eases had lymphatic metastasis and the impli- cation rates of adjacent tissue of AB blood group were obvious higher than those of B blood group （61.5% vs 25.5% , P 〈 0.05 ）. Conclusions The distribution of ABO blood group of gastric cancer had changed in the front and back five years. It clues that non-genetic factors which have the effect on gastric cancer pathogenesis are ever-increasing and there may be some relations between blood group and biological behavior of tumor.
出处
《山东医药》
CAS
2012年第17期16-18,共3页
Shandong Medical Journal
基金
国家自然科学基金资助项目(30360037)
关键词
胃肿瘤
血型
ABO血型系统
临床特点
stomach neoplasms
blood groups
ABO blood-group system
clinical features
