摘要
通过α，β－聚（Ｌ－天冬氨酸）及其衍生物α，β，Ｌ－天冬氨酸和［α，β，Ｌ－（Ｎ－羟乙基）天冬酰胺］共聚物，［α，β，Ｌ－（Ｎ－羟乙基）天冬酰胺］和［α，β，Ｌ－（Ｎ－丁二酸基）天冬酰胺］共聚物为载体，与顺式二氯二氨合铂（Ⅱ）结合，合成了相应高分子－顺铂结合物．研究结果表明，在中性ｐＨ值络合最有效，聚合物－顺铂结合物的体外细胞毒性随结合物浓度增大而增大，但均小于同浓度顺铂毒性．
Three α, β poly( L aspartic acid) derivatives cis platin conjugates were synthesized by conjugation of α,β poly (L aspartic acid), ( α,β,L aspartic acid) [ α,β,L ( N hydroxyethyl) aspartamide] copolymer and [ α,β,L (N hydroxyethyl) aspartamide] [ α,β,L (N succinyl) aspartamide] copolymer with cis dichlorodiammine platinum(Ⅱ) respectively. The polymer carriers were characterized by IR, GPC and intrinsic viscosity. The influence of pH on the conjugation reaction was studied. Cytotoxicity of polymer cis platin conjugates was tested against cervix uteri Hela cells in vitro . The cytotoxicity of polymer cis platin conjugates increases with the increase of concentration of the congugates, but lower than cis platin of the corresponding concentration.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第5期817-820,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
抗肿瘤药物
天冬氨酸
顺铂
结合物
细胞毒性
Polymer antitumor drug, Polymer cis platin conjugates, Cytotoxicity
