摘要
分析苯甲酸雌二醇在奶牛体内的药物代谢动力学过程。试验前对奶牛进行摘除卵巢手术,术后30 d单剂量肌肉注射不孕奶牛催乳注射液(苯甲酸雌二醇+黄体酮),216 h内不同时间17次颈静脉采血,用放射免疫法(RIA)测定血清中雌二醇浓度。结果表明,雌二醇在奶牛体内的药物动力学配置符合有吸收因素的二室开放模型,其药时曲线最佳方程为:C=283.773e-0.0326t+136.748e-0.0133t-420.521e-0.0770t。消除半衰期(t1/2)为(52.232±1.383)h;药时曲线下面积(AUC)为(13525.940±288.114)pg/(mL.h);达峰时间(Tp)为(22.025±0.427)h,达峰浓度(Cp)为(165.385±3.120)pg/mL。试验结果显示,苯甲酸雌二醇在奶牛体内分布广泛,吸收和消除较慢。
The pharmacokinetic process of estradiol benzoate （EB） was analysed so as to provide a theoretical basis for rational use of drug in veterinary clinic. Four cows after ovariectomy were treated with a single dosage of injection of progesterone and estradiol benzoate by intramuscular injection. Blood samples were collected from jugular vein for 17 times in various time within 216 h. Then the serum concentration was measured by the Radio-immunoassay （RIA）. The result showed that the two- compartment model with absorption factor adequately described concentrations of estradiol in serum disposition and the best concentration-time equation was C = 283. 773e^-0.0326t ＋ 136. 748e^-0.0133t - 420. 57e^-0.0770t. The main pharmacokinetics parameters were as follow： the half-life tl/2 was （52. 232± 1. 383） h; AUC was （13525. 940±288. 114） pg/（mL · h） ; Tp was （22. 025±0. 427） h; and Cp was （165. 385±3. 120） pg/mL. It was slow for estradiol to absorb and eliminate in cow, and the distribution of estradiol benzoate was abroad.
出处
《西北农业学报》
CAS
CSCD
北大核心
2009年第3期29-32,共4页
Acta Agriculturae Boreali-occidentalis Sinica
