摘要
分析麻保沙星(Marbofloxacin,MBF)在成年山羊体内的代谢动力学过程。山羊单剂量快速静注MBF 10 mg/kg,16 h内不同时间12次颈静脉采血,用高效液相色谱法测定血药浓度。结果表明,MBF在山羊体内的药物动力学配置符合无吸收因素二室开放模型。其药-时曲线最佳方程为:C=37.6434e-1.1106t+3.6700e-0.0891t;分布半衰期(t1/2α)为(0.6252±0.0299)h,消除相半衰期(t1/2β)为(7.7964±0.4069)h,药-时曲线下面积(AUC)为(75.1943±4.3712)μg/(mL.h),表观分布容积(Vd)为(1.4519±0.0904)L/kg,体清除率(CLB)为(0.1295±0.0119)L/(kg.h)。结果显示,MBF在山羊体内分布迅速而广泛,消除缓慢。
Pharmacokinetic parameters of Marbofloxacin （MBF） in 6 goats were calculated. Goats were treated with a single dosage of MBF （10 mg/ kg） intravenously and rapidly , while the blood samples were collected from jugular vein within 16 hours after giving drug. The concentrations of MBF in serum were determined by high performance liquid chromatography （HPLC） . The results showed that the two-compartment open model with first-order disabsorption factor adequately describes concentrations of MBF in serum disposition and the best concentration-time equations are ： C = 37. 6434e^1.1106t＋3. 6700e^-0.0891t. The primary pharmacokinetic parameters of MBF are ： t1/2α= （0. 6252 ±0. 0299） h , t1/2β= （7. 7964 ±0. 4069） h , AUC= （75. 1943±4. 3712）μg /（mL ·h） , Vd=（1. 4519±0. 0904） L/kg, CLB= （0. 1295 ±_0. 0119） L/（kg. h^-l）. It will be seen that thedistribution of MBF in vivo is rapid and abroad, and the elimination of MBF in vivo is slow.
出处
《西北农业学报》
CAS
CSCD
北大核心
2009年第3期38-41,46,共5页
Acta Agriculturae Boreali-occidentalis Sinica
关键词
麻保沙星
山羊
药物动力学
Marbofloxacin （MBF）
Goats
Pharmacokinetics
