摘要
目的：了解严重烧伤后早期心肌微循环障碍的病理学基础。方法：采用心肌切片苏木素碱性复红苦味酸染色法，以及氢气清除技术测定心肌局部血流量。结果：大鼠严重烧伤后３ｈ心肌缺血性损伤以心肌中层明显，呈“夹心样”变，且左室、右室游离壁及室间隔均出现同样的心肌中层坏死表现。烧伤后３、６、１２ｈ心肌局部血流量明显下降（Ｐ＜０．０５～０．０１）。结论：严重烧伤后早期心肌损伤病理学特征性表现为心肌收缩带形成，中层“夹心样”坏死，损伤呈非均一性，并证明是心肌微循环障碍所致。
Objective: To further explore the pathological basis of myocardial microcirculation obstacle in the early stage after severe burns. Methods: After the model of severe burns was established in rats, the myocardial ischemic lesions were observed with hematoxylin basic fuchsin picric acid staining and the changes of regional myocardial blood flow assessed with hydrogen clearance. Results: The left and right ventricular wall and the septum showed the sandwichlike, uneven necrosis of the midcardium at the 3rd h postburn. The regional myocardial blood flow was significantly decreased at the 3rd, 6th and 12th h postburn (P<0.05～0.01). Conclusion: Pathological features of myocardial lesions including the formation of contracture band and the sandwich-like and uneven necrosis of midcardium are caused by disturbance of myocardial microcirculation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1998年第2期111-113,共3页
Journal of Third Military Medical University
基金
国家自然科学基金
