摘要
采用放射免疫法检测４１例胃肠恶性肿瘤和２０名健康人血清癌胚肮原（ＣＥＡ），糖链抗原（ＣＡ１９－９、ＣＡ５０）含量，并与癌组织学分类、有无淋巴结转移对比分析。结果显示：胃肠肿瘤ＣＥＡ、ＣＡ１９－９、ＣＡ５０值明显高于对照组（Ｐ＜０．０１）。胃癌伴肝、胰转移时ＣＡ１９－９增高尤其显著，胃癌ＣＡ５０值高于大肠癌（Ｐ＜０．０５）。胃肠肿瘤淋巴结转移者三项指标检出率较无转移者高，但差异无显著性。病理分类中胃癌ＣＥＡ阳性率腺癌＞低分化腺癌，ＣＡ１９－９、ＣＡ５０为腺癌＞低分化腺癌＞粘液腺癌。大肠癌ＣＥＡ阳性率乳头状腺癌＞低分化腺癌＞管状腺癌，ＣＡ１９－９、ＣＡ５０为低分化腺癌＞管状腺癌＞乳头状腺癌。三项标志物联检在胃、大肠癌的阳性率为９５．０％和８５．７％。
The levels of serum carcino embryonic antigen(CEA),CA 19 9 and CA 50 were determined in 41 cases of gastrointestinal carcinomas,and 20 health controls by radioimmunoassay.The results showed that the average levels of 3 markers in 41 patients were much higher than those in health controls( P <0.01).The level of CA 50 was significantly higher in gastric cancers than those in large intestine cancers.Very high serum CA 19 9 values(>350 U/ml) were in patient with gastric cancers accompanied liver and pancreas metastasis.The diagnostic rate of 3 markers in gastrointestinal cancers with lymph node metastasis was higher than those without lymph node metastasis.The positive rates of CEA,CA 19 9 and CA 50 in gastric adenocarcinomas were greater than those of low differentiation carcinomas.The positive rate of CEA in large intestine papillocarcinomas was highest,that of tubular adenocarcinomas was lowest and that of low differentiated carcinomas was in middle,the order of CA 19 9 ,CA 50 levels were:low differentiation carcinoma>tubular adenocarcinoma>papillocarcinoma.The diagnostic rate of combination assay of 3 markers was 95.0% in gastric cancers,whereas in large intestine cancers was 85.7%
出处
《实用肿瘤杂志》
CAS
北大核心
1998年第2期85-87,共3页
Journal of Practical Oncology
