摘要
目的:探讨胃癌患者血清血管内皮生长因子(VEGF)和内皮抑素(endostatin)的水平和临床意义。方法:采用ELISA法检测82例胃癌患者及24例健康人血清VEGF及内皮抑素的含量。结果:胃癌组血清VEGF及内皮抑素水平明显高于健康对照组(P<0.01),并且VEGF和内皮抑素水平与肿瘤大小、肿瘤浸润深度及淋巴结转移和TNM分期有关(P<0.01),与组织学类型无关(P>0.05)。VEGF水平高的患者其内皮抑素水平也相应升高,两者呈正相关关系(r=0.423,P<0.01)。结论:胃癌患者血清VEGF及内皮抑素水平升高,与胃癌恶性进展有关,可作为胃癌诊断的辅助标志物,也是胃癌预后不良的潜在指标。
Objective To investigate the serum levels of vascular endothelial growth factor （VEGF） and endostatin in patients with gastric cancer and their clinical significance. Methods Serum levels of VEGF and endostatin were detected by enzyme linked immunosorbant assay （ELISA） in 82 patients with gastric cancer and 24 normal controls. Results Serum levels of VEGF and endostatin in gastric cancer group were significantly higher than those in control group （P〈0.01）. Serum levels of VEGF and endostatin were related to tumor size,the depth of tumor invasion,regional lymph node metastasis and TNM stage （P〈0.01）,but weren＇t related to the histological classification （P〉0.05）. There was a positive correlation between VEGF and endostatin in sera in gastric cancer group. Conclusion The elevated serum levels of VEGF and endostatin in patients with gastric cancer are strongly associated with cancer progression,and they may be useful biomarkers at the diagnosis and prognosis for gastric cancer.
出处
《实用医学杂志》
CAS
北大核心
2010年第4期586-587,共2页
The Journal of Practical Medicine
关键词
胃肿瘤
血管内皮生长因子
内皮抑素
Stomach neoplasm
Vascular endothelial growth factor
Endostatin
