6Nanda S, Bathon JM. Etanercept: a clinical review of current and emerging indications. Expertopin Phamacother, 200415 : 1175-1186.
7Bathon JM, Martin RW, Fleischmarm RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N E ng J Metl, 2000,343 : 1586-1593.
8Klareskog L, van der Heijde D, de Jager Jp, et al. TEMPO(Trial of Etanercept and Methotrexate with Radiographic patient Outcomes) study investiators Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: doubleblind randomised controlled trial. Lancet, 2004,363 : 675-681.
5[25]Fleischmann RM,Schechtman J,Bennett R,et al.Anakinra,a recombinant human interleukin-1 receptor antagonist (rmetHuIL-1ra),in patients with rheumatoid arthritis:A large,international,multicenter,placebo-controlled trial.Arthritis Rheum,2003,48 (4):927-934
6[2]Xi Z,Zhang J,Shen B,et al.Type Ⅱ collagen-specific T cells mediate the onset of arthritis.US.Chin J Lymphology Oncol,2004,3 (4):198-202
7[6]Felson DT,Anderson JJ,Boers M,et al.American College of Rheumatology.Preliminary definition of improvement in rheumatoid arthritis.Arthritis Rheum,1995,38 (6):727-735
8[7]Smolen JS,Kalden JR,Scott DL,et al.Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis:a double-blind,randomised,multicentre trial.European Leflunomide Study Group.Lancet,1999,353(9149):259-266
9[8]Strand V,Cohen S,Schiff M,et al.Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate.Leflunomide Rheumatoid Arthritis Investigators Group.Arch Intern Med,1999,159 (21):2542-2550
10[9]Cohen S,Cannon GW,Schiff M,et al.Two-year,blinded,randomized,controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate.Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group.Arthritis Rheum,2001,44 (9):1984-1992
9Aruett FC, Edwonhy SM, Bloch DA, et al. The American Rheu- matism As - soeiation 1987 revised criteria for the classification of rheumatoid arthritis[ J ]. Arthritis Rheum, 1988,31 ( 3 ) :315 - 324.
10Ramos - Casals M, Brito Zeron P, Munoz S, et al. Autoimmune diseas induced by TNF - targeted therapies: analysis of 233 cases [ J 1. Medicine, 2007,86:242 - 251.