摘要
目的:观察小续命汤对急性缺血性中风模型大鼠血浆一氧化氮(NO)含量和一氧化氮合酶(NOS)活力的影响,探讨其在治疗急性缺血性中风中的作用机制。方法:应用线栓法制备大鼠急性脑梗死模型,给予中药小续命汤灌胃10d后,测定血浆中NO含量和NOS的活力。结果:中药治疗组血浆NO含量和NOS活力明显下降,与模型组相比差异显著(P<0.01)。结论:中药复方小续命汤可降低急性脑梗死大鼠血浆NO含量和NOS的活力,抑制缺血性脑损伤。
Objective To observe the change of the level of nitric oxide （NO） and the activity of nitric oxide synthase （NOS）, and to discuss the mechanism of curing function in the acute cerebral infarction （ACI）. Methods Using suture methods to induce rats mode of acute cerebral infarction, giving a certein Xiaoxuming decoction by intragastric administration. And determinting the level of NO and the activity of NOS. Results There were the reduction of the level of NO and the activity of NOS in treatment group. Compared to model group, there were significant difference （P 〈 0.01）. Conclusion Traditional Chinese medicine of Xiaoxuming decoction can lower the level of NO and the activity of NOS obviously. It can suppresses the ischemic brain damage.
出处
《深圳中西医结合杂志》
2009年第1期13-15,26,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
广西研究生教育创新计划资助项目
