摘要
目的 了解急性脑血管病患者血浆NO(一氧化氮 )含量的变化情况 ,探讨NO在急性脑血管病发生发展过程中的作用和意义。方法 采用硝酸酶还原法分别测定 47例脑梗死和 42例脑出血患者入院时、发病后第 3d、第 7d、第 2 1d的NO含量。结果 脑梗死组前 3次的血浆NO含量均比对照组低 ,差异有显著性 (P <0 0 1) ;第 2 1d的血浆NO含量比入院时高 (P <0 0 5 ) ,且与正常对照组比较无明显差异 (P >0 0 5 )。脑出血组 4次检测的血浆NO含量均比对照组低 (P <0 0 1) ,且连续 4次检测的血浆NO含量没有明显变化 ,差异无显著性。脑梗死组前 3次的血浆NO含量与脑出血组同期的血浆NO含量比较无明显差异 (P >0 0 5 ) ;脑梗死组第2 1d的血浆NO含量比脑出血组第 2 1d的血浆NO含量高 (P <0 0 1)。结论 急性脑血管病患者存在低水平的血浆NO含量 ,脑出血患者的低水平血浆NO含量比脑梗死患者持续时间更长 ,NO可能参与了急性脑血管病的病理过程。
Objective To explore the changes of plasma nitric oxide (NO) concentration in patients with acute cerebrovascular disorders,and gain insight into the function and significance of NO in the origin and development of acute cerebrovascular disorders.Methods The object consists of 47 patients with an acute cerebral infarction(group A)and 42 patients with an acute cerebral hemorrhage(group B).Plasma NO concentration was measured at the moment of hospitaliz and 3 days,7 days,21 days after onset of symptoms by the method of nitrate reductase.Results The concentration of group A in former three times was statistically lower than those of controls(P<0.01),but the plasma NO concentration in the 21 days was higher than that of at the moment of hospitaliz (P>0.05),and there was no statistically different from those of controls (P>0.05),in group B the values of all four times had no difference.There were on statistically difference in group A and group B at the former three times too (P>0.05),but the valve of group A at 21 days was higher than that of group B (P<0.01).Conclusion There were lower plasma NO level in patients with acute cerebrovascular disorders,and the patient with an acute cerebral hemorrhage continue this tendency longer.Then we can conclude that NO may take part in pathologic process of acute cerebrovascular disorders.
出处
《河南实用神经疾病杂志》
2004年第1期7-8,共2页
Henan Journal of Practical Nervous Diseases
基金
广东省科委 2 0 0 2年重点攻关项目 (0 0G0 0 2 - 0 1 - 63)
关键词
急性脑血管病
血浆
NO
一氧化氮
病理学
Cerebral infarction
Cerebral hemorrhage
Nitric oxide
Nitrate reductase
