摘要
目的探讨膀胱癌基底膜中层粘蛋白、胶原蛋白Ⅳ与纤维连接蛋白分布表达的相关性。方法用免疫组织化学方法测定35例膀胱移行上皮癌和3例低分化鳞状上皮癌肿瘤组织基底膜层粘蛋白(LN)、胶原蛋白Ⅳ(Col Ⅳ)和纤维连接蛋白(FN)含量与分布。结果病理级别高、浸润性生长的膀胱移行上皮癌,基底膜LN、Col Ⅳ和FN一样,阳性染色少,分布不连续;反之,病理级别低、非浸润性生长的肿瘤,基底膜LN、Col Ⅳ也和FN一致,阳性染色多,分布呈连续性。低分化鳞状上皮癌基底膜LN、Col Ⅳ和FN分布含量同样呈正相关。结论膀胱肿瘤基底膜LN、Col Ⅳ和FN分布含量高度一致,它们的丧失可作为肿瘤恶性度高的指标之一。
Objective In order to explore the relationship among laminin (LN), collagen type Ⅳ (Col Ⅳ) and fibronectin (FN) express on at basement membrane (BM) in patients with bladder carcinoma and their clinical implications. Methods Distribution of LN, Col Ⅳ and FN at BM were studied by immunoperoxi- dase technique in 35 patients with bladder transitional cell carcinoma and 3 with squamous cell carcino- ma. Results The poorer the tumour differentiation or the deeper the tumour invasion, the more the loss of LN, Col Ⅳ and FN at BM in patients with bladder transitional cell carcinoma. The expressions of LN, Col Ⅳ and FN at BM in patients with squamous cell carcinoma were reduced. Conclusions The losing de- grees of LN and Col Ⅳ corresponded to the losing degree of FN. The absence of LN, Col Ⅳ as well as FN at BM can be used to predict the malignant tendency in patients with bladder neoplasm.
出处
《中华实验外科杂志》
CSCD
北大核心
1998年第1期46-47,共2页
Chinese Journal of Experimental Surgery
