摘要
目的:观察肿瘤坏死因子（TNF）对培养的牛脑微血管内皮细胞释放内皮素-1（ET－1）的刺激作用及粉防己碱（Tet）对ET－1释放的抑制作用。方法：放免测定法。结果：TNF在（l～100μg·L(-1)）之间能剂量依赖性的促进牛脑微血管内皮细胞释放ET-1，Tet（10(－6)～10(－4)mol·L(－1)）能拮抗TNF诱导的ET－1释放并呈量效关系。
To observe the effect ofTNF on the production of ET-1 by culturedbovine ceretromicrovascular endothelium cellsand inhibitory effect of tetrandrine (Tet ).METHOD: Radioimmunoasssay. RESULTS:TNF stimulated ET-1 production of culturedBCEC in a dose-dependent manner at concertration from 1 to 100 μg. L-1. The stimulating effect of TNF on ET-1 production was inhibitedby Tet in a doseudependent fashion (10(-6)～10(-1)mol. L(-1)). CONCLUSION: TNF stimulatedET-1 production of BCED, and Tet inhibited thestimulating effect of TNF.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第5期442-443,共2页
Chinese Pharmacological Bulletin
