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FAK与人类肿瘤的关系 被引量：2

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摘要 粘着斑激酶（focal adhesion kinase，FAK）属于胞浆内非受体蛋白酪氨酸激酶（NRPTKs），位于细胞和细胞外基质结合部位整合素（integrin）构成的灶性粘附复合体（focal adhesion complex）上,具有多种功能，与细胞的多蛋白信号系统的形成、生存和游走等有关，临床研究显示其在多种人类肿瘤中均有表达,与肿瘤的侵袭与转移特性关系密切，
作者 敖洪峰 敖金平 刘勇 路名芝
机构地区 南昌大学医学院 江西省新余市水北医院 江西省人民医院病理科
出处 《实验与检验医学》 CAS 2008年第5期533-536,共4页 Experimental and Laboratory Medicine
关键词 人类肿瘤 受体蛋白酪氨酸激酶 FAK 细胞外基质 粘着斑激酶 侵袭与转移 结合部位 信号系统
分类号 R730.2 [医药卫生—肿瘤] R739.41 [医药卫生—肿瘤]
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参考文献27

  • 1[1]Aguirre Ghiso JA.Inhibition of FAK sigualing activated by urokinase receptor induces dormancy in human carcinoma cells in vivo[J].Onengene,2002,21(16):2513～2524.
  • 2[2]Liu G,Guibao CD,Zheng J.Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase[J].Mol Cell Biol,2002,22(8):2751～2760.
  • 3[3]Schaller MD,Borgman CA,Cobb BS,et al.pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions[J].Proc Nail Acad Sci,1992,89:5192～5196.
  • 4[4]Lira Y,Han 1,Jeon J,et al.Phosphorylation of focal adhesion kinase at tyrosine 861 is cmeial for Ras transformation of fibroblnsts[J].J Biol Chera,2004,279(28):29060～29065.
  • 5[5]Roy S,Ruest PJ,Hanks SK.FAK regulates tyrosine phesphorylatian of CAS,paxillin,and PYK2 in cells expressing v-Src,but is not a critical determinant of v-Src transformation[J].J Cell Biochem,2002,84(2):377～388.
  • 6[6]Calderwood DA,Shattil SJ,Ginsberg MH.Integrin and actin filament:reciprocal regulation of cell adhesion and sigualing[J].J Biol Chem,2000,275(30):22～607.
  • 7[7]Suzawa M,Tamura Y,Fukumoto S,et al.Stimulation of Smad 1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway:a possible mechanism for collagen-dependent osteoblaatic differentiation[J].J Bone Miner Res,2002,17(2):240～248.
  • 8[8]Aikawa R,Nagai T,Kudoh S,et al.Integrins play a critical role in mechanical stress-induced p38 MAPK activation[J].Hypertension,2002,39(2):233～238.
  • 9[9]Matter ML,Ruoslahti E.A signaling pathway from the α5 v β1 and α v β3 integrins that elevates bcl-2 transcription[J].J Biol Chem,2001,276(30):27757～27763.
  • 10[10]Hanger-Glaser I,Fan RS,Perez-Salazar E,et al.PDGF and FGF induce focal adhesion kianse(FAK) phnsphorylation at Ser-910:dissociation from Tyr-397 phosphorylation and requirement for ERK activation[J].J Cell Physiol,2004,200(2):213～222.

同被引文献27

  • 1Fraley SI,Feng Y,Krishnamurthy R,et al.A distinctive role for focal adhesion proteins in three-dimensional cell motility[J].Nat Cell Biol,2010,12(6):598-604.
  • 2Zheng Y,Lu Z.Paradoxical roles of FAK in tumor cell migration and metastasis[J].Cell Cycle,2009,8(21):3474-3479.
  • 3Chu PY,Huang LY,Hsu CH,et al.Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration,proliferation,and tumorigenesis[J].J Biol Chem,2009,284(30):20215-20226.
  • 4Schaller MD.Paxillin:a focal adhesion-associated adaptor protein[J].Oncogene,2001,20(44):6459-6472.
  • 5Das A,Yaqoob U,Mehta D,et al.FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9[J].Arterioscler Thromb Vasc Biol,2009,29(4):562-570.
  • 6Lau GM,Lau GM,Yu GL,et al.Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro[J].Dig Dis Sci,2009,54(7):1465-1474.
  • 7Golubovskaya VM,Conway-Dorsey K,Edmiston SN,et al.FAK overexpression and p53 mutations are highly correlated in human breast cancer[J].Int J Cancer,2009,125(7):1735-1738.
  • 8Chatzizacharias NA,Kouraklis GP,Theocharis SE.Clinical significance of FAK expression in human neoplasia[J].Histol Histopathol,2008,23(5):629-650.
  • 9Rajapakse N,Kim MM,Mendis E,et al.Carboxylated chitooligosaccharides(CCOS)inhibit MMP-9 expression in human fibrosarcoma cells via down-regulation of AP-1[J].Biochim Biophys Acta,2006,1760(12):1780-1788.
  • 10Jagadeeswaran R,Surawska H,Krishnaswamy S,et al.Paxillin is a target for somatic mutations in lung cancer:implications for cell growth and invasion[J].Cancer Res,2008,68(1):132-142.

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实验与检验医学
2008年 第5期

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