摘要
目的:探讨胃癌组织中VEGF、CD34、VEGF-C和VEGFR-3的表达情况及临床意义。方法:采用免疫组化方法测定81例胃癌组织VEGF、CD34、VEGF-C和VEGFR-3表达情况,并结合患者的临床病理资料进行分析。结果:81例胃癌组织中MVD平均值为(42.95±14.79)个/视野,范围为13.00～68.33个/视野,VEGF、VEGF-C、VEGFR-3阳性表达率分别为74.1%、64.2%、67.9%。VEGF的表达与肿瘤的TNM分期、浸润深度、淋巴结转移有关,CD34的表达与肿瘤的分化程度、TNM分期、浸润深度、淋巴结转移有关,VEGF-C的表达与肿瘤的分化程度、浸润深度、淋巴结转移有关,VEGFR-3的表达与肿瘤的浸润深度、淋巴结转移有关。结论:VEGF、CD34、VEGF-C和VEGFR-3的表达与胃癌的浸润转移密切相关。
Objective： To investigate the expression of VEGF, CD34, VEGF-C and VEGFR-3 in gastric carcinoma. Method： The expression of VEGF, CD34, VEGF-C and VEGFR-3 were detected in eighty-one cases of gastric carcinoma by using immunohistochemistry. Results： In 81 cases, micro-vessel density ranged from 13.00 to 68.33; VEGF, VEGF-C and VEGFR-3 positive rate were 74.1%, 64.2 % and 67.9 %. The expression of VEGF and CD34 were significantly related with TNM staging, tumor invasion and lymph node metastasis. The expression of VEGF-C and VEGFR-3 were significantly related with tumor invasion and lymph node metastasis. The expression of VEGF-C and CD34 were significantly related with differentiation, Conclusion： The expression of VEGF, CD34, VEGF-C and VEGFR-3 are closely correlated with invasion and metastasis of gastric carcinoma.
出处
《现代生物医学进展》
CAS
2008年第10期1921-1923,共3页
Progress in Modern Biomedicine
基金
国家自然科学基金(No:30772716)
