摘要
目的探讨淋巴瘤与ＥＢ病毒的关系。方法应用聚合酶链反应（ＰＣＲ）技术检测霍奇金病（ＨＤ）和非霍奇金病（ＮＨＤ）中ＥＢ病毒ＤＮＡ。结果ＥＢ病毒ＤＮＡ的检出率分别为：ＨＤ４８６％（１８／３７），各亚型中淋巴细胞为主型（ＬＰ）２８６％（２／７），结节硬化型（ＮＳ）２０％（２／１０），混合型（ＭＣ）７５％（９／１２），淋巴细胞消减型（ＬＤ）６２５％（５／８）；ＮＨＤ３２％（８／２５），其中Ｔ细胞淋巴瘤（ＴＭＬ）６３６％（７／１１），Ｂ细胞淋巴瘤（ＢＭＬ）７１％（１／１４）。结论国内淋巴瘤的发病可能与ＥＢ病毒的感染有一定关系，其中以ＨＤ中的ＭＣ和ＬＤ及ＮＨＤ中的ＴＭＬ与ＥＢ病毒的关系较密切。
PURPOSE To study the viral origin of lymphomas.METHODS The polymerase chain reaction (PCR) technique was used to test the EB virus in 37 cases of Hodgkin's disease (HD),which included the following subtypes:nodular sclerotic (NS) n=10;mixed cellular (MC) n=12;lymphocytic predominant (LP) n=7;lymphocytic depleted (LD) n=8.The 25 nonHodgkin's cases (NHD) included 11 cases of Tcell lymphoma (TML) and 14 cases of Bcell lymphoma (BML).RESULTS EB virus genomic DNA sequences were detected in 486% of HD (18/37),in which 2 from the 7 cases of LP (286%);2 from the 10 cases NS (20%);9 from the 12 cases of MC (76%) and 5 from the 8 cases of LD (625%).8/25 of NHD (32%),in which 7 from the 11 cases of TML and 1 from the 14 cases of BML.CONCLUSIONS This study suggested that the pathogenesis of HD and TML may be related to the EB virus infection.
出处
《中国癌症杂志》
CAS
CSCD
1997年第4期289-291,共3页
China Oncology
关键词
淋巴瘤
聚合酶链反应
EB病毒
lymphoma
EpsteinBarr virus
polymerase chain reaction
