摘要
采用免疫组化方法研究了８２例小儿何杰金淋巴瘤标本内ＥＢ病毒编码的潜在膜蛋白（ＬＭＰ），发现６７例ＬＭＰ阳性，其中混合细胞型阳性率为９０．９％，年龄在３～５岁患者阳性率达１００％，６～１０岁患者阳性率为７５％，而１１～１４岁的患者阳性率只有６２％。这提示ＥＢ病毒和何杰金淋巴瘤关系非常密切，年龄越小，阳性率越高，混合细胞型与ＥＢ病毒的关系比其它各型更加密切。
pecimens from 82 children with Hodgkin′s lymphoma were studied by immunohistochemical technique for Epstein一Barr virus encoded latent membrane protein (LMP).LMP was demonstrated in 67 cases 81.7%,the positive rate for the mixed cellular subtype was 90.9%。 The positive rate for the 3一5year old group of patients was 100%, 75%for the 6一10 year old group and only 62.5% for the 11一14 year old group。These findings suggest that Epstein一Barr virus is strongly associated with Hodgkin′s lymphoma, the younger the age,the stronger the association Mixed cellular subtype of Hodgkin′s lymphoma had the strongest,association with Epstein一Barr virus among all subtypes。
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1994年第4期224-226,T045,共4页
Chinese Journal of Pathology
关键词
淋巴瘤
膜蛋白
EB病毒
何杰金
Lymphoma Epstein一Barr Virus Membrane proteins
