摘要
目的：探讨超声引导下经皮瘤内注射酒精（PEI）、肝动脉化疗栓塞联合酒精（TAcE＋PEI）局部综合介入疗法对直径5～8cm肝癌患者的治疗疗效。方法：选择2000年6月～2007年12月经上述2种介入方法治疗的肝癌患者24例，其中分别以酒精治疗16例、综合介入治疗8例，并与同期56例肝癌手术治疗患者的生存率和复发率进行比较。结果：①2种方法介入治疗及手术治疗患者1、3、5年累计生存率比较均以外科手术组最高（91．9％）；2种方法介入治疗患者1年生存率由高至低依次为酒精组（86．4％）、综合治疗组（81．8％）；3年生存率由高至低依次为综合治疗组（52．3％）、酒精组（48．5％）；5年生存率由高至低依次为酒精组（25．8％）、综合治疗组（25．0％）；2组患者1、3、5年生存率比较差异均无统计学意义（P〉0．05）；②手术治疗组（8．9％）与综合治疗组局部复发率比较差异无统计学意义（P〉0．05），而显著低于酒精治疗组（P〈0．05）；③2组介入治疗部位以外肝癌病灶复发率为62．5％～80．0％，组间比较差异无统计学意义（P〉O．05）。结论：酒精和局部综合介入治疗可作为无法切除大肝癌的治疗选择。若肿瘤血供丰富首选局部介入综合疗法。术后严密监测、及时补充治疗是提高介入综合治疗疗效的关键。
Objective. To investigate the efficacy of percutaneous ethanol injection （PEI） and local eomp re- hensive intervention of transcatheter arterial chemoembolization （TACE） combined with PEI on patients with 5 8 cm liver cancer. Methods：A total of 24 patients with liver cancer were conducted by ultrasound guided mul- tiple interventions from 2000-- 2007 were enrolled as investigated objects. In 24 patients 16 Patients were treated with PEI, 8 cases with local comprehensive treatment. Their survival rate was compared with that of 56 patients undergone concurrently liver cancer operation. Results： （1） Compared with other groups, the 1st, 3rd and 5th year cumulative survival rates of surgical operation were the highest （91.9 % ）. The 1 st year cumulative survival rates of ultrasound guided intervention groups were in-descending order of PEI （86.4 % ）, local comprehensive treatment （81.8 % ） ; and the 3 rd year cumulative survival rates were in descending order of PAI （55.0 % ） , local comprehensive treatment（52.3 % ） ; and the 5th year cumulative survival rates were in descending order of PEI （25.8 % ）, local comprehensive treatment （25.0 % ）. （2）The operational group as the control group（8.9 % ） was significantly lower than those of PEI , and local comprehensive intervention group （P〈0.05） ; QFollow up by the 5th year, the recurrences at the sites beside the treated and metastatic sites varied 62. 5 % -80. 0% there were no significant differences between all groups （ P 〉 0. 05）. Conclusions. Comprehensive sequential therapy, postoperative monitoring recurrence and reinforcing treatment in time were the essential points for improving the survival rate of patients with liver cancer.
出处
《内蒙古医学杂志》
2008年第7期807-809,共3页
Inner Mongolia Medical Journal
关键词
介入性超声检查
肝肿瘤
治疗
Interventional ultrasonography
Liver neoplasms
Therapy
