摘要
目的开发一种简便有效、经济安全的肝癌治疗新方法。方法对２１例肝癌患者共３０个结节在超声引导下细针穿刺经皮瘤内注射超过８０℃的蒸馏水，利用其高温、低渗作用杀灭肿瘤。肿瘤直径０．９～３．９ｃｍ，每个瘤灶注射１～６次，注射剂量８～６０ｍｌ。结果治疗后４个瘤灶消失，１４个缩小，１２个未增大。直径缩小或不变的肿瘤，影像学上呈囊性化趋向，ＣＴ增强扫描动脉期无强化，原血清甲胎蛋白（ＡＦＰ）值升高者显著下降，经组织学检查的瘤灶证实完全坏死。注射过的瘤灶无局部复发，肝内远膈部位复发６例。治疗副作用仅见短暂的局部烧灼痛、低热、一过性转氨酶轻度升高。结论本疗法最显著的优点是安全性高，可适用于肝功能较差的病例和某些特殊部位的肿瘤。
Objective\ To devise a new local therapeutic modality for liver cancer with the characteristics of safety, reliable effacacy, convenience and low costs. Methods\ Percutaneous hyperthermal distilled water injection therapy (PHDI) was performed on 21 patients with total of 30 tumor nodules, by injecting hot distilled water (>80℃) into the tumor under ultrasound guidance to ablate the lesion with the action of hyperthermia and hypoosmotism. The lesions ranged in diameter from 0.9 cm to 3.9 cm. Each lesion underwent 1￣6 times of injection, and the total therapeutic volume of distilled water per lesion varied from 8 ml to 60 ml. Results\ After treatment, 4 lesions disppeared, 14 shrinked and 12 did not change in size. All existing lesions presented trend of cystic change by imaging examination and no enhancement in CT scanning. Serum α fetoprotein (AFP) values decreased remarkedly in all patients whose pretreatment values were high. Some lesions underwent histological examination proved complete necrosis. No local recurrence was found and 6 cases of remote recurrence were encountered. The side effects of this procedure were transient local burning pain, low fever and mild elevation of transaminase. Conclusions\ Because of its high safety, PHDI is suitable for patients with poor liver function and ablation of tumors at some special sites.
出处
《中华超声影像学杂志》
CSCD
1999年第4期225-228,共4页
Chinese Journal of Ultrasonography
关键词
介入性超声检查
肝细胞癌
蒸馏水
病灶内注射
Ultrasonography, interventional\ \ Carcinoma, hepatocellular\ \ Distilled water\ \ Injections, intralesional
