摘要
目的探讨COX-2与VEGF-C在大肠癌组织中的表达及与临床病理因素之间的关系。方法运用免疫组化方法检测54例大肠癌组织中COX-2与VEGF-C的表达。结果COX-2和VEGF-C蛋白在大肠癌中的表达阳性率分别为72.22%(39/54)和64.81%(35/54),COX-2与VEGF-C表达之间存在显著的相关性(P<0.001);在伴有淋巴结转移的大肠腺癌中,COX-2与VEGF-C的阳性表达率分别为87.5%(21/24)和91.67%(22/24),转移组与非转移组相比较均有显著性差异(P<0.05);COX-2蛋白表达与肿瘤大小、浸润深度、Dukes分期呈负相关(P<0.05),与组织分化、性别、年龄等临床病理因素无关(P>0.05)。VEGF-C表达与浸润深度、Dukes分期呈负相关(P<0.05),与组织分化、性别、年龄、肿瘤大小等临床病理因素无关(P>0.05)。结论COX-2蛋白与VEGF-C共表达可增加大肠癌转移和侵袭能力,其检测有助于大肠癌恶性程度评价及临床预后的判断。
Objective To study the expressions, of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor-c （VEGF-C） in colorectal carcinoma and their correlations to the clinicopathologic factors. Methods The expressions of COX-2 and VEGF-C were detected by irnmunohistochemical staining （S-P method） in 54 cases of colorectal carcinoma. Results The positivity rates of COX-2 and VEGF-C in colorectal carcinoma were 72.22% and 64.81% respectively. A significant correlation was found between the expressions of COX-2 and VEGF-C （P 〈0. 001）, which were also related to several clinicopathologic factors, including lymph node metastasis, deepth of invasion, tumor size, and Duke＇s stage （P〈0. 01）, but not related to other clinicopathological factors Conclusion In human colorectal carcinoma, the expressions of COX-2 and VEGF-C are correlated and significantly associated with the patient＇s prognosis by means of increasing the invasive and metastatic ability.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2008年第4期320-323,共4页
Chinese Journal of Histochemistry and Cytochemistry
基金
安徽省教育厅自然科学研究项目(2006kj391B)
