摘要
采用共沉淀和离子交换两种方法制备出了布洛芬(IBU)/层状双氢氧化物(LDH)插层化合物:in-situ-MgAl-IBU和ex-situ-MgAl-IBU样品。红外光谱、X射线衍射和热重分析研究表明,上述样品中IBU离子均成功的插入到了LDH层间,且LDH层间几乎所有的NO3-都被IBU离子取代。在磷酸缓冲溶液中考察了其缓释性能,结果表明,ex-situ-Al-IBU的缓释性能明显优于in-situ-MgAl-IBU产品,说明采用不同的方法可以制备出不同缓释性能的IBU/LDH插层化合物产品。
Ibuprofen （IBU）-layered double hydroxide coprecipitation （in-situ-MgAl-IBU） arid ion-exchange thermal properties of the above two compounds were （LDH） intercalated compounds were prepared by （ex-situ-MgAl-IBU） methods. The structures and determined by FT IR, XRD and TG analysis. The results showed that the IBUs ions were intercalated into the LDHs host successfully by complete ion- exchange of NO3^-. The drug release properties were studied in phosphate buffer and the results showed that the release time of the ex-situ-MgAl-IBU sample was longer than the in-situ-MgAl-IBU. Th.is means that IBU/LDH intercalated compounds with different release property can be synthesized by different methods.
出处
《化学世界》
CAS
CSCD
北大核心
2008年第8期449-452,共4页
Chemical World
基金
安徽省高等学校青年教师科研资助计划项目(2006jq1236)
黄山市科技计划重点项目(2005ZG-08)
关键词
共沉淀法
离子交换法
布洛芬
层状双氢氧化物
缓释
coprecipitation
ion-exchange
ibuprofen
layered double hydroxide
controlled release
