摘要
目的制备布洛芬凝胶，并进行质量标准的研究。方法用卡渡姆等辅料配制布洛芬凝胶，用高效液相色谱法测定布洛芬的含量并检查其有关物质；色谱柱：Lichrosorb C18柱（4．6mm×150mm，5μm）；流动相：乙腈-水（58：42）（用磷酸调节pH值至3．0），流速1mL·min^-1，检测波长：264nm。结果布洛芬在50．02～400．16μg·mL^-1浓度范围内，线性关系良好（r=0．9999）；布洛芬平均回收率（n=9）分别为99．0％（RSD=0．44％），100．5％（RSD=0．56％），99．2％（RSD=0．35％）。结论用卡波姆等药用辅料可制备出理想的布洛芬凝胶，布洛芬凝胶的质量标准可靠。
Objective To study the preparation and quality standard of ibuprofen gel. Methods Carbomer 940 and other supplementary materials were used to prepare ibuprofen gel, and a reverse phase high performance liquid chromatography （RP-HPLC） was established to determine its content and other substances by using a chromatograph column： Lichrosorb C18 column（4.6 mm × 150 mm,5 μm） ,mobile phase ： acetonitrile-water （ 58 ： 42） （ pH adjusted to 3.0 with phosphoric acid） with a flow rate of 1.0 mL·min^-1 and detection wavelength at 264 nm. Results The standard curve was linear in the range of 50.02 - 400.16 μg·mL^-1 （ r = 0. 999 9）. The average recoveries （ n = 9 ） were 99.0% （ RSD = 0.44% ）, 100.5% （ RSD = 0.56% ） ,99.2% （ RSD = 0. 35% ） , respectively. Conclusion The materials such as carbomer can prepare the ideal ibuprofen gel with a standard and reliable quality.
出处
《医药导报》
CAS
2006年第1期52-54,共3页
Herald of Medicine
