摘要
采用焙烧还原法制备了牛磺酸/层状双氢氧化物插层复合物(TAU-LDH)和布洛芬/层状双氢氧化物插层复合物(IBU-LDH)。研究了插层复合物中TAU和IBU在模拟人体内肠道pH值(pH=7.4)的磷酸缓冲溶液(PBS)中的缓释性能。XRD和FT-IR分析表明,TAU和IBU阴离子成功进入到LDHs层间形成插层复合物,IBU-LDH插层复合物的结晶性能优于TAU-LDH。UV-Vis分析表明,存在于LDHs层间的TAU和IBU在缓冲溶液中具有明显的缓释特性。复合物中的TAU 40 min释放85%,180 min释放完全;IBU 40 min释放88%,180 min释放完全。IBU-LDH插层复合物的药物缓释特性优于TAU-LDH插层复合物。
Taurine layered double hydroxide （TAU-LDH） and ibuprofen layered double hydroxide （IBU-LDH） were prepared with calcinated-hydration method, by using taurine （TAU） and ibuprofen （IBU） as interlayer anions. XRD and FT-IR were used to characterize the structure of intercalation compounds. Drug release characteristics of TAU-LDH and IBU-LDH were investigated with a dissolution test in a phosphate buffer dissolution （PBS）. The UV-Vis test results show that the drug release in the interlayer of LDHs is a slow process. TAU-LDH compound releases 85% of TAU in 40 min and 100% of TAU in 180 min, while IBU-LDH compound releases 88% oflBU in 40 min and 100% of IBU in 180 min. This data suggested that these drug-inorganic hybrid materials can be used as an effective drug delivery system.
出处
《矿物学报》
CAS
CSCD
北大核心
2012年第4期481-485,共5页
Acta Mineralogica Sinica
基金
国家自然科学基金(批准号:40972033)
中国科学院矿物学与成矿学重点实验室合作研究基金(编号:KLMM20110202)
广西自然科学基金(2010GXNFC013003)
广西研究生教育创新计划项目(2009105960805M03)
关键词
层状双氢氧化物
牛磺酸
布洛芬
插层作用
药物缓释
layered double hydroxide
taurine
ibuprofen
intercalation
drug controlling release
