摘要
目的:观察依那普利联合左旋氨氯地平对2型糖尿病(DM)合并原发性高血压(EH)患者的降压效果及对胰岛素抵抗、尿微量白蛋白、肾功能的影响。方法:120例2型DM合并EH患者随机分为2组(各40例),分别为对照组1口服苯磺酸左旋氨氯地平2.5mg,qd;对照组2给予依那普利片10mg,qd;1组治疗组(40例)依那普利和左旋氨氯地平,剂量同治疗组。疗程均为12周。每天监测1次血压,若2周后血压未降至正常,则左旋氨氯地平增至5mg,依那普利增至15mg,疗程12周。所有患者在治疗前2周停用影响肾功能药物及其他降压药物。比较治疗前后各组患者的收缩压收缩压、舒张压、空腹血糖、空腹胰岛素、尿微量白蛋白、血肌酐和血尿素氮及不良反应。结果:治疗组降低血压及24h尿白蛋白排的效果明显优于对照组1和对照组2,差异有统计学意义(P<0.05)。结论:依那普利和左旋氨氯地平联合治疗2型DM合并EH更加合理有效,而且无明显不良反应。
OBJECTIVE To observe the effect of enalapril combined with levoamlodipine besylate on blood pressure ,insulin resistance, urine microalbumin and kidney function in patients with type 2 diabetes mellitus complicated with hypertension. METHODS The 120 patients with type 2 diabetes mellitus complicated with hypertension were randomly divided into 3 groups：2 control groups （n = 40, respectively） and treating group （combined drug treatment group） （n = 40） . patients in control group 1 were treated by enalapril 10 mg, qd; control group 2 were treated with Levoamlodipine Besylate 2. 5 mg, qd; patients in treating group were treated with enalapril combined with levoamlodipine besylate： enalapril 10 mg, bid combined with Levoamlodipine Besylate 2. 5 mg, qd; the treatment course was 12 weeks for all the three groups. The systolic blood pressure （SBP） , diastolic blood pressure （DBP）, microalbumin （Alb）, serum creatinine （Scr）, blood urea nitrogen （BUN）, fasting blood glucose （FBG）,fasting blood insulin （FBI）, and drug adverse reactions were detected before and after the treatment in both groups. RESULTS The blood pressure lowering proteinuria reducing effects in treating group were significantly better than those both in control group 1 and 2 （P〈0. 05） . CONCLUSION Enalapril combined with levoamlodipine besylate is reasonable and effective in treating type 2 diabetes mellitus complicated with hypertension , without obvious side effects.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第14期1190-1192,共3页
Chinese Journal of Hospital Pharmacy
