摘要
目的探讨癫痫患儿丙戊酸钠血药浓度与剂量等因素的相关性。方法126例癫痫儿童按体重口服相应剂量(10～20mg·kg-1·d-1)德巴金糖浆,3～5天后采用高效液相法测定丙戊酸钠血药浓度并采用Pearson相关及偏相关分析结果。结果Pearson相关分析发现体重与口服剂量,体重与年龄,年龄与剂量之间存在正相关相关系数分别为0.55、0.70、0.45(P<0.001),剂量与血药浓度之间也为正相关相关系数为0.33(P<0.01)。偏相关分析发现剂量、体重与丙戊酸钠血药浓度的偏相关系数分别为0.55(P<0.001)、-0.30(P<0.05)。结论样本研究发现2岁以下癫痫患儿丙戊酸钠血药浓度与剂量、体重存在一定相关关系,与年龄的相关性不显著。临床用药需考虑剂量、体重对血药浓度的影响。
Objective To investigate the relationship between plasma levels of sodium valproate and oral doses and other factors in epileptic children. Methods 63 cases of epileptic children took valproate syrup according to their body weights （10-20mg·kg^-1·d^-1）.Examined their plasma levels using high performance liquid chromatographic method and analyzed the results using Pearson correlations and partial correlations. Results There were positive correlations between body weights and doses,body weights and ages ,doses and plasma levels.Their Pearson coefficient were 0.55,0.70,0.45 （P〈0.001）.There were positive correlations between doses and sodium valproate plasma levels and Pearson coefficient was 0.33 （P〈0.01）,also.The partial correlation coefficients between plasma levels and doses,weight were 0.55 （P〈0.001）,-0.30 （P〈0.05）. Conclusion For less than two years epileptic children in small sample study there were some correlations beteen sodium valproate plasma levels and doses ,weight and no correlations beteen plasma levels and ages.When using sodium valproate for epileptic children should consider the affectiveness of doses and ages to plasma levels.
出处
《中国现代医药杂志》
2008年第7期41-43,共3页
Modern Medicine Journal of China
关键词
丙戊酸钠
血药浓度
相关分析
偏相关
Sodium valproate Plasma levels Analysis of correlations Partial eorrelations
