摘要
目的分析丙戊酸钠治疗儿童癫痫的血药浓度监测结果,指导临床合理用药。方法对126例癫痫患儿使用丙戊酸钠达稳态血药浓度后,采用荧光偏振免疫法(FPIA)测定其血药浓度,并分析结果。结果有61.90%的儿童血药浓度在50～100μg/ml范围内,27.78%低于50μg/ml,10.32%高于100μg/ml。结论癫痫患儿服用丙戊酸钠在体内的血药浓度个体差异大,应及时检测其血药浓度,制定个体化给药方案对控制癫痫的发作有重要的意义。
Objective In Order to guide clinical rational administration, the result from monitoring serum concentration of children with epilepsies treated with sodium valproate was analyzed. Methods The drug serum concentration in 126 epileptic cases was determined fluorescence polarization immunoassay （FPIA）.The results had been analyzed. Results Effective rate of the drug serum concentration within 50-100 μ g/ml was 61.9% Effective rate of the drug serum concentration less than 50 μ g/ml was 27.8%; Effective rate of the drug serum concentration more than 100 μ g/ml was 10. 32%.Conclusion There exists big individual variance among drug serum concentration of epileptic people treated with sodium valproate, it is suggested that an individual administrated scheme should be applied in clinical practice.
出处
《国际医药卫生导报》
2006年第18期12-14,共3页
International Medicine and Health Guidance News
关键词
癫痫
丙戊酸钠
血药浓度监测
Epilepsies Sodium valproate Monitoring serum concentration
