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脑缺血时乳酸的生成、转运、代谢和利用 被引量：16

Lactate production,metabolism,transportation and usage during cerebral ischemia
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摘要 近年来对乳酸的研究表明,乳酸不仅是脑缺血/缺氧的代谢产物,同时也担负起在特殊情况下对神经元的供能作用。其主要在星形胶质细胞产生,又被神经元摄入胞内提供能量。此过程中单羧酸转运体(MCTs)充当着转运的角色。对乳酸的深入研究将有助于全面认识乳酸在脑缺血中的病理生理意义。 Recent study has shown lactic acid （ LA ） is not only waste metabolite during cerebral-ischemia, but also energy supply for the neuron in the pathophyiological situation. LA is made mainly in neuronal aerobic, and in turn taken in neuron, in the way of transportation by monocarboxylate transporter（MCTs）. It is helpful to understand LA pathophysiological significance with the further study of LA.
作者 胡珺 陈芸芸 邢东明 王伟 杜力军
机构地区 清华大学生物科学与技术系药物药理学研究室
出处 《中国药理学通报》 CAS CSCD 北大核心 2008年第3期284-288,共5页 Chinese Pharmacological Bulletin
基金 教育部博士学科点专项科研基金资助项目(No20060003072) 国家自然科学基金资助项目(No30572340 30500651)
关键词 乳酸 脑缺血 能量代谢 lactic acid cerebral ischemia energy metabolism
分类号 R-05 [医药卫生] R329.25 [医药卫生—人体解剖和组织胚胎学]
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参考文献34

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二级参考文献13

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共引文献24

同被引文献174

引证文献16

二级引证文献116

中国药理学通报
2008年 第3期

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