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缺血后适应对脑保护作用的研究进展

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摘要 缺血后适应是指在再灌注早期，重复给予几次短暂的血管闭塞与再通的过程，可明显减轻随后长时间再灌注引起的组织损伤。缺血后适应具有脑保护作用，与缺血预适应不同，缺血后适应在再灌注开始之后进行，符合临床治疗特点，有望在临床中开展。
作者 吴浩 蒋丽丹
机构地区 首都医科大学宣武医院神经外科
出处 《中国脑血管病杂志》 CAS 2010年第8期445-448,共4页 Chinese Journal of Cerebrovascular Diseases
基金 北京市科技新星资助项目(2008B72)
关键词 脑缺血 缺血预处理 细胞保护 缺血后适应
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献28

  • 1Na HS,Kim YI,Yoon YW,et al.Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia[J].Am Heart J,1996,132(1 Pt 1):78-83.
  • 2Murry CE,Jennings RB,Reimer KA.Preconditioning with ischemia:a delay of lethal cell injury in ischemic myocardium[J].Circulation,1986,74 (5):1124-1136.
  • 3Grech ED,Ramsdale DR.Termination of reperfusion arrhythmia by coronary artery occlusion[J].Br Heart J,1994,72(1):94-95.
  • 4Zhao ZQ,Corvera J S,Halkos ME,et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning[J].Physiol Heart Circ Physiol,2003,285(8):579-588.
  • 5Zhao H,Sapolsky RM,Steinberg GK.Interrupting reperfusion as a stroke therapy:ischemic postconditioning reduces infarct size after focal ischemia in rats[J].J Cereb Blood Flow Metab,2006,26(9):1114-1121.
  • 6Gao X,Ren C,Zhao H.Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning[J].J Neurosci Res,2008,86 (11):2505-2511.
  • 7Ren C,Gao X,Niu N,et al.Delayed postconditioning protects against focal ischemic brain injury in rats[J].PLoS ONE,2008,3(12):3851.
  • 8Dietrich WD,Busto R,Alonso O,et al.Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats[J].J Cereb Blood Flow Metab,1993,13(4):541-549.
  • 9Perez-Pinzon MA.Neuroprotective effects of ischemic preconditioning in brain mitochondria following cerebral ischemia[J].J Bioenerg Biomembr,2004,36 (4):323-327.
  • 10Dumas TC,Sapolsky RM.Gene therapy against neurological insults; sparing neurons versus sparing function[J].Trends Neurosci,2001,24 (12):695 -700.

二级参考文献13

  • 1闵小芬,李卫平,王绍斌,何婷,尹艳艳,明亮.黄芪提取物对局灶性脑缺血再灌注损伤的抗氧化及线粒体保护作用[J].中国药理学通报,2005,21(2):216-219. 被引量：41
  • 2毛张凡,杜心灵.缺血后处理对心肌缺血再灌注损伤的保护作用[J].国外医学（心血管疾病分册）,2005,32(5):293-295. 被引量：3
  • 3Xu Z,Cohen M V,Downey J M,et al.Attenuation of oxidant stress during reoxygenation by AMP 579 in cardiomyocytes[J].Am J Physiol,2001,281:H2585-9.
  • 4Broadhead M W,Frca M,Kharbanda R K.KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo[J].Circulation,2004,10(12):2077-81.
  • 5Hall E D,Braughler J M.Central nervous system trauma and stroke Ⅱ Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation[J].Free Rad Biol Med,1989,6(3):303-13.
  • 6He Y Y,Hsu C Y,Ezrin A M,et al.Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion[J].Am J Physiol,1993,265(1 Pt 2):H252-6.
  • 7Imaizumi S,Woolworth V,Fishman R A,et al.Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats[J].Stroke,1990,21(9):1312-7.
  • 8Chen J,Simon R.Ischemic tolerance in the brain[J].Neurology,1997,48(2):306-11.
  • 9Davis D P,Patel P M.Ischemic preconditioning in the brain[J].Curr Opini Anaesthesiol,2003,16(5):447-52.
  • 10Downey J M,Cohen M V.We think we see a pattern emerging here[J].Circulation,2005,111:120-1.

共引文献24

中国脑血管病杂志
2010年 第8期

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