摘要
为了进一步证实一氧化氮（ＮＯ）在急性缺血性肾衰（ＩＡＲＦ）发生发展中的作用，采用ＮＯ供体ＳＩＮ１对大鼠ＩＡＲＦ模型进行腹主动脉持续灌注３小时。结果发现：ＮＯ供体输入体内可在肾内迅速产生高浓度ＮＯ，可明显改善肾缺血再灌注后的肾皮质缺血，减轻肾功能及组织学损害。结果表明：ＮＯ下降参与了缺血再灌注的肾功能损害，是ＩＡＲＦ发生发展的重要因素之一。ＮＯ缺乏主要导致肾血流量下降，继而ＧＲＦ下降。应用ＮＯ供体直接提供外源性ＮＯ，提高肾内ＮＯ水平可以有效增加肾缺血再灌流后肾血流，改善肾功能，是防治ＩＡＲＦ又一新途径。
Nitric oxide donor SIN 1 was continuously infused into the abdominal aorta of ischemic acute renal failure (IARF)rat model for 3 hours.The results revealed that SIN 1 would increase the level of NO in the kidney,markedly improve the renal cortex blood flow and would provide significant protection to the renal function and morphological structure of rat kidney following renal ischemiareperfusion injury.The lower level of NO would result in renal ischemia function impairment and would thus play an important role in the pathogenesis of IARF.Infusion of NO donor provides exogenous NO in vivo and might be a new means of preventing and treating IARF.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第8期461-464,共4页
Chinese Journal of Urology
