摘要
采用家兔急性肾缺血再灌流损伤模型，研究白细胞在肾损伤中的作用。实验分缺血再灌流（ischemicreperfusionIR）和对照组。均去右肾，检测在缺血前、缺血60min和再灌60min、120min时混和静脉血中的白细胞总数和再灌120min时左肾系数（LRC）、肾组织中的白细胞数以及过氧化服质（LPO）含量．并在光镜下对再灌120min时的肾小管的病理变化进行评分。结果表明：IR在再灌流120min时，以上指标同对照组比较，差异显著（P＜0．05或P＜0．01）。血中白细胞数与LPO、LRC、肾小管评分的改变呈正相关（P＜0．05），肾组织中白细胞数与LRC、肾小管评分呈正相关（P＜0．05）。提示：白细胞在急性肾缺血再灌流损伤中起着重要的作用。
The role of WBC in renal injury caused by acute ischemia and reperfusion was investi-gated in rabbit. The experiments were performed in rabbits after right nephrectomy in both ischemiareperfusion (IR) group and control group. The WBC in blood was counted respectively before ischemi-a, 60min after ischemia, 60min and 120min after reper fusion. Left renal coefficient (LRC), Lipid per-oxides (LPO) and WBC in kidney were determined and the pathologic changes in tubules were scoredin light microscope at 120min after reperfusion. The results indicate that there are significant differ-ences in the above indexes comparing the IR group with contrcl at 120min after reperfusion (P<0. 05or 0.01 ), and the changes of WBC in blood were positively correlated to the LPO, LRC and scores ofthe tubules (P<0.05). It is suggested that WBC may play an important role in renal injury causedby ischemia and reperfurfusion
出处
《泸州医学院学报》
1995年第2期87-90,共4页
Journal of Luzhou Medical College
基金
四川省科委基金
关键词
白细胞
肾损伤
再灌注损伤
肾缺血
White blood cell (WBC)
Acute ischemia and reperfusion
Renal injury
