摘要
利用电喷雾电离技术对葛根素的结构和质谱裂解规律进行研究,用Mass frontier3.0软件辅助解析了主要特征碎片离子及其裂解途径。结果发现,葛根素主要通过D环的糖苷碎裂而发生裂解,出现碎片m/z399、381、363、351、335、321。碎片m/z399裂解成碎片m/z381,碎片m/z381又裂解成碎片m/z363和351为ESI-MS裂解特征。
Structure and MS/MS fragment pathway of pueratin were elucidated with electron spray ionization mass spectrometry. The characteristic ions and fragment mechanism were explained by Mass Frontier 3.0. Pueratin mainly fragmented on the glycoside of D ring. The characteristic ions of pueratin were m/z 399,381,363,351,335,321 and m/z 399 fragment to m/z 381, ion m/z 381 fragment to m/z 363 and m/z 351. The result provides important information for the drug metabolism and structural modification research of puerarin.
出处
《质谱学报》
EI
CAS
CSCD
2007年第4期224-228,共5页
Journal of Chinese Mass Spectrometry Society
基金
国家自然科学基金(30472057)
北京市自然科学基金(7052007)
暨北京市教委科技发展计划项目(KM200410025003)资助
关键词
葛根素
电喷雾电离质谱
结构
puerarin
electron spray ionization mass spectrometry （ESI-MS）
structure
