摘要
目的研究多种肿瘤标记物蛋白芯片诊断系统用于肠道肿瘤的诊断价值。方法采用多种肿瘤标记物蛋白芯片诊断系统测定分析30例肠道恶性肿瘤患者,20例良性肠道肿瘤患者,30例对照人群和30例肠道肿瘤术后复发患者血清中的组织特异性抗原(TPS)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖原125(CA125)、糖原153(CA153)、糖原242(CA242)、糖原199(CA199)、前列腺特异性抗原(PSA)、铁蛋白(FER)。结果30例肠道肿瘤患者血清有27例肿瘤标记物为阳性(阳性率为90.0%);20例良性肠道肿瘤患者血清有3例肿瘤标记物为阳性(阳性率为15.0%);30例对照人群血清3例肿瘤标记物为阳性(阳性率为10.0%);30例肠道肿瘤术后复发患者血清30例肿瘤标记物为阳性(阳性率为100.0%)。在肿瘤组和复发组中以TPS的阳性率最高(分别为83.3%、90.0%),其次为CEA、CA199和CA242。结论TPS在肿瘤的诊断中是1种敏感性较高的肿瘤标记物。多种肿瘤标记物蛋白芯片诊断系统的应用对肠道肿瘤患者的良恶性判断有一定的临床应用价值,对术后复发转移的判断也有一定的应用价值。
Objective To investigate the feasibility of tumor markers protein chip diagnosis system in the diagnosis of intestinal tumor. Methods Objective Serum levels of 9 tumor markers （TPS, CEA, CA153, NSE, CA125, CA242, CA199, PSA, FER） were evaluated by tumor marker protein chip diagnosis system from 30 patients with malignant intestinal tumor,20 patients benign intestinal tumor, 30 healthy controls and 30 patients with postoperative recurrent disease. Results At least one tumor marker was positive in 27 of the 30 patients （90.0%） with malignant intestinal tumors,3 of the 20 patients （ 15.0% ） with benign intestinal tumor,3 of the 30 normal controls （ 10.0% ） and 30 of 30 patients （ 100.0% ） with postoperative recurrent diseases. The most common positive tumor marker in patients with malignant intestinal and recurrent tumor was TPS, followed by CEA, CA199 and CA242. Conclusion TPS was a sensitive tumor marker in the diagnosis of intestinal tumor. It is helpful in the differential diagnosis of malignant intestinal tumor from benign intestinal diseases, and in the monitoring of tumor recurrence after surgical treatment of the intestinal carcinoma
出处
《实用癌症杂志》
2007年第6期592-594,共3页
The Practical Journal of Cancer
