摘要
为探讨血清组织多肽特异性抗原 (TPS)在胃肠道肿瘤患者血清中的表达水平及其对胃肠道肿瘤的临床应用价值 ,采用酶联免疫吸附法 ,测定 1 1 4例健康体检者和 5 6例胃肠道肿瘤患者的血清TPS、癌胚抗原 (CEA)和低聚糖类肿瘤相关糖类抗原(CA1 99)水平。结果显示胃肠道肿瘤患者血清TPS、CEA和CA1 99表达水平及检测阳性率均显著高于正常对照组 (P <0 0 1 )。TPS检测阳性率显著高于CEA和CA1 99(P <0 0 1 ) ,在转移性胃肠道肿瘤中TPS的阳性检出率较CEA、CA1 99高 (P <0 0 5 ) ,以远处淋巴结转移的阳性检出率最高(92 8% ) ,表达水平以肝转移最高。TPS、CEA和CA1 99检测阳性率在已发生转移较未转移高 (P <0 0 5 )。胃肠道肿瘤患者经有效治疗后血清TPS、CE及CA1 99水平均明显下降 ,尤其以TPS下降幅度较为显著。提示血清TPS是检出胃肠道肿瘤非常敏感的标志物 ,尤其是淋巴结转移患者 ,对胃肠道肿瘤早期诊断、病情判断和疗效评价等均有重要价值。
To investigate the expression and clinical value of serum TPS(tissue polypeptide specific antigen) assay in patients with gastrointestinal tract tumor. Fifty six patients with gastrointestinal tract tumors were studied in contrast with 114 healthy people. The levels of serum TPS, CEA, and CA199 were assayed with ELISA. The results showed that the levels and positive rates of serum TPS, CEA and CA199 were significantly higher in gastrointestinal tract tumor group than those in the normal healthy group ( P <0 01). The positive rate of serum TPS was highest when there was distant lymph node metastasis (92 8%). The level of serum TPS was highest when liver metastasis occurred. The positive rates of serum TPS, CEA and CA199 were significantly higher in patients with metastasis than those without metastasis. The levels of the serum TPS, CEA and CA199 declined significantly after the patients had received efficacious treatment. Among them, serum TPS showed more remarkable declination, denoting that the serum TPS is a very useful tumor marker, with high specificity and sensitivity, for gastrointestinal cancers, especially when lymph node metastasis occurs. Therefore, serum TPS assay is valuable in early diagnosis and for the evaluation of treatment for GI tract carcinomas.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2003年第6期535-536,共2页
Medical Journal of Chinese People's Liberation Army
基金
瑞典康乃格生物工程研究所资助项目 (编号 98C0 1 )
