摘要
目的探讨肝细胞生长因子(HGF)及其受体(c-Met)在胃癌组织中表达的意义。方法采用即用型免疫组化染色法检测44例胃癌、20例慢性浅表性胃炎、10例慢性萎缩性胃炎和16例胃溃疡组织中HGF/c-Met的表达。结果慢性浅表性胃炎组织细胞内均无HGF/c-Met表达,HGF在胃癌、慢性萎缩性胃炎和胃溃疡组织中表达阳性率分别为72.7%(32/44)、20%(2/10)和37.5%(6/16),胃癌HGF阳性率显著高于慢性萎缩性胃炎组(P<0.005)及胃溃疡组(P<0.025);c-Met在胃癌、慢性萎缩性胃炎和胃溃疡组织中表达阳性率分别为77.3%(34/44)、40%(4/10)和37.5%(6/16),胃癌c-Met阳性率也显著高于慢性萎缩性胃炎组(P<0.05)及胃溃疡组(P<0.025)。结论胃癌组织中存在HGF和c-Met的共同表达,可能是促进肿瘤恶性演变的生物学行为,也为胃癌的治疗提供一条新的有效途径。
Objective To investigate the role of expression of hepatocyte growth factor （HGF） and its receptor （c-Met） in gastric cancer. Methods The expression of HGF and c-Met was detected with SABC immunohistochemistry in 44 specimens of gastric cancer, 20 chronic superficial gastritis, 10 chronic atrophic gastritis and 16 gastric ulcer tissues. Results No positive expression of HGF/c-Met was found in the chronic superficial gastritis specimens. The positivity rates of HGF in the gastric cancer was 72.7% （32/44）, significantly higher than that in chronic atrophic gastritis [20% （2/10）, P〈0.005] and gastric ulcer [37.5% （6/16）. P〈0.025]. The positivity rates of c-Met in gastric cancer [77.3% （34/44）] was also significantly higher than that in chronic atrophic gastritis [40% （4/10）, P〈0.05] and gastric ulcer [37.5% （6/16）, P〈0.025]. Conclusion Co-expression of HGF and c-Met in gastric cancer may promote the progression of the malignancy, and also opens a new pathway for the therapy of gastric cancer.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第11期1771-1773,共3页
Journal of Southern Medical University
基金
深圳市龙岗区科技局资助项目(2005064)
关键词
肝细胞生长因子
受体
胃肿瘤
hepatocyte growth factor
receptor
stomach neoplasms
