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2-氰基-4’-甲基联苯合成方法综述 被引量：6

Review of Synthesis of 2-Cyano-4'-methylbiphenyl
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摘要 2-氰基-4′-甲基联苯(沙坦联苯)是合成血管紧张素Ⅱ拮抗剂类药物的天键中间体。综述了沙坦联苯的合成方法,并着重讨论了过渡金属催化偶联法在沙坦联苯合成中的应用。 2-Cyano-4'-methylbiphenyl(sartanbiphenyl)is a key intermediate of angiotensinⅡreceptor antagonists.The synthesis methods of sartanbiphenyl reported in the literature were reviewed,and the importance of transition metal catalyzed cross-couplings in preparing sartanbiphenyl were mainly discussed.
作者 张翘楚 郭孟萍 ZHANG Qiao-chu;GUO Meng-ping(Institute of Coordination Catalysis College of Chemistry and Bioengineering,Yichun University,Yichun 336000)
机构地区 宜春学院化学与生物工程学院配位催化研究所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第11期819-822,共4页 Chinese Journal of Pharmaceuticals
基金 江西省教育厅科技计划项目(赣教技字[2007]310号) 宜春市重点科技计划项目(宜科字[2006]56号)
关键词 2-氰基-4’-甲基联苯 沙坦联苯 合成 过渡金属 催化 偶联法 综述 2-cyano-4'-methylbiphenyl sartanbiphenyl synthesis transition metal catalysis cross-coupling review
分类号 R972 [医药卫生—药品]
  • 相关文献

参考文献17

  • 1Bernhart CA, Perreaut PM, Ferrari BP, et al. A new series of imidazolones: highly specific and potent nonpeptide AT 1 angiotensin Ⅱ receptor antagonists [J]. J Med Chem, 1993, 36 (22) : 3371-3380.
  • 2Ries UJ, Mihm G, Narr B, et al. 6-Substituted benzimidazoles as new nonpeptide angiotensin Ⅱ receptor antagonists: synthesis, biological activity, and structure-activity relationships [J]. J Med Chem, 1993, 36 (25): 4040-4051
  • 3姚其正,张志祥,林宏志,吕刚.2-氰基-4′-甲基联苯合成方法的研究[J].药学进展,2001,25(3):149-152. 被引量：9
  • 4魏开红.2-氰基-4’-甲基联苯的合成[J].化学与生物工程,2004,21(3):39-39. 被引量：3
  • 5Carini D J, Duncia JV, Aldrich PE, et al. Nonpeptide angiotensin Ⅱ receptor antagonists: the discovery of a Series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives [J].J Med Chem, 1991, 34 (8) : 2525-2547.
  • 6Sain B, Sandhu JS. A facile one-pot synthesis of unsymmetrical biaryl-2-carbonitriles by novel reaction of ylidenemalononitriles with dienamines[J]. J Org Chem, 1990, 55 (8) : 2545-2546.
  • 7Asai T, Kumai S. Preparation of biphenyl compounds: JP, 08109143 [P]. 1996-04-30.
  • 8Kageyama H. Method for producting an asymmetric biaryl derivative: EP, 571770[P]. 1993-12-01. (CA 1996, 125: 86290)
  • 9Katsura T, Shiratani H, Sugi K, et al. Process for preparing 2-cyanobiphenylc ompound: EP, 854135 [P]. 1998-01-28. (CA 1998, 129: 122451)
  • 10Tsuji J. Palladium Reagents and Catalysts[M]. Wiley: Chichester, 1995.

二级参考文献15

  • 1Kageyama, Hiroyuki. Method for producing an asymmetric biaryl derivative[P]. EP 0517 770A1,1993-04-27.
  • 2Katsura, Tada shi. Process for preparing 2-cyanobiphenyl compound[P].EP 0854 135A2,1998-01-21.
  • 3Eric Riguet, Moud Alami, Gérard Cahiez. Versatile palladium-catalyzed arylation of organomanganese chlorides by aryl bromides[J].Journal of Organometallic Chemistry,2001, 624:376-379.
  • 4Monteith M J. Recent developments in transition metal catalysed couplings[J]. Speciality Chemicals, 1998 : 436-438.
  • 5Miyaura N, Yanggi T, Suzuki A. The Palladium-Catalyzed Cross-Coupling Reaction of Phenylboronic Acid with Haloarenes in the Presence of Bases[J]. Synthetic Communication, 1981,11:513-519.
  • 6Carini D J, Duncia J V, Aldrich P E, et al. Nonpeptide An giotensin Ⅱ Receptor Antagonists: The Discovery of a Series of N- (Biphenylylmethyl) imidazoles as Potent, Orally Ac tive Antihypertensives [J]. J Med Chem, 1991,34: 2525-2543.
  • 7Tadashi K, Hiroshi S, Kiyosi S, et al. Process for preparing 2-cyanobiphenyl compound [P], EP 0854135, 1998- 01-28.
  • 8Kageyama H. Method for producting an asymmetric biaryl derivative[P]. EP 571770,1993-12-01.
  • 9Asai J, Kumai S. Preparation of biphenyl compounds[P],JP 08109143,1996-04-30.
  • 10Herrmann W A, Brossmer C, Oefele K, et al. Palladacycles as Struturally Defined Catalysts for the Heck Olefination of Chloro-and Bromoarents[J]. Angew Chem Int Ed Engl, 1995,34: 1844-1848.

共引文献10

同被引文献69

  • 1陈安成,范玉华,毕彩丰,赵宇,孙梦轲.沙坦联苯的合成工艺[J].广东化工,2012,39(12):52-53. 被引量：1
  • 2杨莉,蒋青峰,曲彩红.氯沙坦的合成[J].中国新药杂志,2006,15(22):1948-1950. 被引量：6
  • 3严琳,张益峰,何明阳,陈群.MnCl_2催化偶联合成2-氰基-4′-甲基联苯中杂质成因分析[J].江苏工业学院学报,2007,19(1):14-18. 被引量：2
  • 4Gottfried S. Process For the preparation of tetrazole derivatives from organo boron and organo aluminium azides[P]. WO: 2 005 014 602, 2005-02-17.
  • 5Boris S, Daniela M, Daniel K. Safe and fast tetrazole formation in ionic liquids[J]. Tetrahedron, 2007, 63 (2): 492-496.
  • 6张福利.抗高血压药物[A].高等药物化学选论[C].北京:化学工业出版社.2006.275-304.
  • 7Russell R K, Murray W V. Efficient synthesis of 5-(1'-methyl [1,1'-biphenyl]-2-yl)-lH-tetrazole[J]. J Org Chem, 1993, 58 (18) : 5 023-5 024.
  • 8Thomas K, Peter F, Juergeu D, et al. Process for the preparation of substituted biphenyhetrazoles [P]. DE: 4 313 747, 1994-11-03.
  • 9Oda R, Tanaka H, Miyashige R, et al. Producton of 5- ( ( 1,1 '-biphenyl)- 1H-tetrazoles [P ]. JP: 07 002 805, 1995- 01-06.
  • 10Finnegan W G, Henry R A, Lofquist R. An improved synthesis of 5-substituted tetrazoles [J]. J. Amer. Chem. Soc., 1958, 80 (15): 3 908-3 911.

引证文献6

二级引证文献12

中国医药工业杂志
2007年 第11期

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