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冠心病患者血浆apelin水平的变化 被引量：7

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摘要 目的:观察冠心病患者血浆apelin水平变化,探讨其在冠状动脉粥样硬化中可能的作用。方法:选取冠脉造影阴性者29例为对照组;造影确诊冠心病患者46例(冠心病组),分别在支架置入前及支架置入后24h经动脉采血,用放射免疫法测定血浆apelin水平。结果:(1)冠心病患者支架置入前血浆apelin水平明显低于对照组(P<0.01);支架置入后24h血浆apelin水平明显高于置入前的水平(P<0.01),而接近对照组水平(P>0.05)。(2)冠心病患者支架置入前血浆apelin水平与冠脉狭窄的程度有负相关性(r=-0.366,P<0.05),与冠状动脉病变评分有明显负相关性(r=-0.467,P<0.01)。结论:冠心病患者血浆apelin水平在介入治疗后升高,apelin可能参与冠状动脉粥样硬化的病理生理过程。
作者 张明 童静 应斌宇 唐疾飞 练红 范小芳 龚永生 杨鹏麟
机构地区 温州医学院附属第二医院ICU 温州医学院附属第二医院急诊科 温州医学院附属第二医院心内科 温州医学院基础学院机能实验室
出处 《实用医学杂志》 CAS 2007年第21期3361-3362,共2页 The Journal of Practical Medicine
基金 温州市科委基金项目(编号:Y2005A017)
关键词 冠状动脉疾病 冠状动脉硬化 APELIN 冠状动脉狭窄
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献11

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同被引文献82

  • 1余洋,黄德嘉.Apelin对心肌细胞肥大的影响[J].心脏杂志,2006,18(2):185-189. 被引量：16
  • 2吴哲兵,余静,李光迪,郭雪娅,常鹏,何大渊.替米沙坦对高血压病患者血浆apelin-12水平的影响[J].临床荟萃,2006,21(21):1530-1532. 被引量：15
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  • 6Yao F, Sumners C, O' Rourke S T, et al. Angiotensin Ⅱ increases GABAB receptor expression in nucleus tractus solitarii of rats [J]. Am J Physiol Heart Circ Physiol, 2008,294(6): H2712-H2720.
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实用医学杂志
2007年 第21期

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