摘要
以碳酸钠为缚酸剂,摩尔比为1︰1的2,6-二甲基苯胺与氯乙酰氯反应合成了中间体2-氯-N-(2,6-二甲基苯基)乙酰胺;在强碱乙醇钠作用下,2-吡咯烷酮再与2-氯-N-(2,6-二甲基苯基)乙酰胺经亲核取代合成了目标化合物奈非西坦。探讨了影响中间体和奈非西坦产率的因素,在乙醇钠、2-氯-N-(2,6-二甲基苯基)乙酰胺和2-吡咯烷酮的摩尔比为2︰1︰2、反应时间为2 h的较佳工艺条件下,产品总收率达81%。
The 2-chloro-N-（2,6-dimethyl） phenyl acetamide was obtained from 2,6-dimethylaniline and chloroacetyl （molar ratio of 1 1） using sodium carbonate as antacid agent. Then sodium ethoxide was used as base, the nucleophilic substitution of 2-pyrrolidone with the intermediate provided nefiracetam. The influencing factors of the reaction yield were studied. The optimum reaction conditions were as follows： n（ethanol sodium） ： n（2-chloro-N-（2,6-dimcthyl）phenyl acetamide） ： n（2-pyrrolidonc） was 2 ： 1 ： 2 and reaction time was 2 h. The total yield of the product was 81%.
出处
《广东化工》
CAS
2007年第9期89-91,共3页
Guangdong Chemical Industry
基金
国家自然科学基金资助项目(No.20472080)
河南工业大学博士启动基金项目(No.150213)
